Mitochondria as a pharmacological target: magnum overview

A Olszewska, A Szewczyk - IUBMB life, 2013 - Wiley Online Library
Mitochondria, responsible for energy metabolism within the cell, act as signaling organelles.
Mitochondrial dysfunction may lead to cell death and oxidative stress and may disturb …

The role of mitochondria in cellular toxicity as a potential drug target

D Wu, X Wang, H Sun - Cell Biology and Toxicology, 2018 - Springer
Mitochondrial malfunction is related to aging and to the onset of many diseases, such as
obesity/diabetes, cancer, and cardiovascular and neurodegenerative diseases. The …

Mitochondria as a pharmacological target

A Szewczyk, L Wojtczak - Pharmacological reviews, 2002 - ASPET
Mitochondria play a central role in energy metabolism within the cell. Mitochondrial
dysfunctions lead to various neurodegenerative disorders and to the so-called …

Targeting mitochondria: strategies, innovations and challenges: the future of medicine will come through mitochondria

M Edeas, V Weissig - Mitochondrion, 2013 - Elsevier
Mitochondrial dysfunction has been associated with the aging process and a large variety of
human disorders, such as cardiovascular and neurodegenerative diseases, cancer …

Mitochondria and drugs

R Scatena - Advances in mitochondrial medicine, 2012 - Springer
Mitochondria play a central role in the life and death of cells. They are not merely the centre
for energy metabolism, but are also the headquarters for different catabolic and anabolic …

Delivery to mitochondria: a narrower approach for broader therapeutics

SS Malhi, RSR Murthy - Expert opinion on drug delivery, 2012 - Taylor & Francis
Introduction: Research has revealed a relationship between mitochondrial dysfunction and
diseases such as diabetes, ischemia–reperfusion injury, cancer and many more. As a result …

Mitochondrial pharmaceutics

V Weissig, SM Cheng, GGM D'Souza - Mitochondrion, 2004 - Elsevier
Since the end of the 1980s, key discoveries have been made which have significantly
revived the scientific interest in a cell organelle, which has been studied continuously and …

[HTML][HTML] Mitochondrial pharmacology

RAJ Smith, RC Hartley, HM Cocheme… - Trends in pharmacological …, 2012 - cell.com
Mitochondria are being recognized as key factors in many unexpected areas of biomedical
science. In addition to their well-known roles in oxidative phosphorylation and metabolism, it …

Editorial (thematic issue: mitochondrial biogenesis: pharmacological approaches)

T Valero - Current pharmaceutical design, 2014 - ingentaconnect.com
Organelle biogenesis is concomitant to organelle inheritance during cell division. It is
necessary that organelles double their size and divide to give rise to two identical daughter …

Mitochondria make a come back

IE Scheffler - Advanced drug delivery reviews, 2001 - Elsevier
This review attempts to summarize our present state of knowledge of mitochondria in
relation to a number of areas of biology, and to indicate where future research might be …