Mitochondria are best known as the sites for production of respiratory ATP and are essential
for eukaryotic life. They have their own genome but the great majority of the mitochondrial …

Apart from reliable management of the “powerhouse” of the cell, mitochondria faithfully
orchestrate a diverse array of important and critical functions in governing cellular signaling …

Introduction: One target of toxicity caused by cardiac drugs is the mitochondrion. This review
focuses on the mitochondrion-toxic effects of cardiac drugs and the extent to which …

As the understanding of mitochondria and their importance for the cell and organism is
developing, increasing evidence is demonstrating the organelle to be intricately involved in …

The loss of neurons at any stage of life is a catastrophic event. These post-mitotic cells lack
the ability to regenerate and as such their loss is an unthinkable finality. The most widely …

Increasing evidences suggest that mitochondrial dysfunction plays an important role in the
pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD) …

Mitochondria play a pivotal role in cellular function, not only acting as the powerhouse of the
cell, but also regulating ATP synthesis, reactive oxygen species (ROS) production …

Disruption of mitochondrial function is a common feature of inherited mitochondrial diseases
(mitochondriopathies) and many other infectious and non-infectious diseases including viral …

Once considered exclusively the cell's powerhouse, mitochondria are now recognized to
perform multiple essential functions beyond energy production, impacting most areas of cell …

Introduction: Mitochondrial diseases are a group of heterogeneous disorders for which no
curative therapy is currently available. Several drugs are currently being pursued as …