Evidence of a genetic control of pain has led to efforts to exploit genotyping information from
pain patients for the development of analgesics and for the selection of pharmacological …

Background Opioid analgesics are frequently prescribed to manage acute and chronic pain,
but individual differences in opioid response make effective pain control in all patients an …

Chronic pain affects approximately one in five adults, resulting in a greatly reduced quality of
life and a higher risk of developing co-morbidities such as depression. Available treatments …

Chronic pain is a classic example of gene× environment interaction: inflammatory and/or
nerve injuries are known or suspected to be the etiology of most chronic pain syndromes …

Genetic pain loss includes congenital insensitivity to pain (CIP), hereditary sensory
neuropathies and, if autonomic nerves are involved, hereditary sensory and autonomic …

Tailoring an individual patient's pain treatment is paramount to decreasing patient suffering
and diminishing morbidity. Performing pharmacogenomic (PGx) testing can help guide …

Purpose This paper summarizes current knowledge of pain-related and analgesic-related
pathways as well as genetic variations involved in pain perception and management …

Although considerable progress has been made in identifying pathophysiologic
mechanisms of acute and chronic pain, this knowledge has not translated to the …

Clinical practice of pharmacologic pain therapy struggles with a large interindividual
variability of the wanted and unwanted effects of the administered analgesics. An important …