High CD8+ T cell infiltration in colorectal cancer (CRC) should suggest a favorable
prognosis and a satisfactory response to immunotherapy; however, the vast majority of …

Currently, cancer ranks as the second leading cause of death worldwide, and at the same
time, the burden of cancer continues to increase. The underlying molecular pathways …

Background Cellular senescence is a state of irreversible cell growth arrest and senescence
cells permanently lose proliferation potential. Induction of cellular senescence might be a …

Background: TRIB3 is a human homologue of Drosophila tribbles. Previous studies have
shown that TRIB3 controls the cell growth through ubiquitination-dependent degradation of …

Background & Aims Activation of Wnt signaling to β-catenin contributes to the development
of colorectal cancer (CRC). Expression of tribbles pseudo-kinase 3 (TRIB3) is increased in …

Lung cancer is the most common cause of cancer-related mortality worldwide. Here, we
report elevated expression of tribbles homolog 2 (TRIB2) in primary human lung tumors and …

Intrinsic and acquired resistance to chemotherapy is the fundamental reason for treatment
failure for many cancer patients. The identification of molecular mechanisms involved in …

Summary Tribbles homolog 2 (Trib2) was identified as a downregulated transcript in
leukemic cells undergoing growth arrest. To investigate the effects of Trib2 in hematopoietic …

METHODS: TRIB3 expression and its correlation with clinicopathological features was
evaluated in 123 patients with RCC. A series of cytological experiments were performed to …

T-cell exhaustion represents a progressive loss of T-cell function. The inhibitory receptor PD-
1 is known to negatively regulate CD8+ T cell responses directed against tumor antigen, but …