Xanthine oxidase (XO) expression is increased in the failing heart, and animal studies in
rodents and dogs showed that XO inhibition with allopurinol can improve left ventricular (LV) …

Using a highly specific assay that minimizes enzyme inactivation in vitro, we found that
rabbit myocardial tissue contained low levels of xanthine oxidase (XO) and xanthine …

Reactive oxygen species, in particular superoxide, have been closely linked to the
underlying pathophysiology of ischemic cardiomyopathy: superoxide not only mediates …

Myocardial ischemia initiates a series of cellular reactions which unless checked will
culminate in cell death and tissue necrosis. Although reperfusion provides a means of …

BACKGROUND: Oxidative stress is implicated in cardiac remodeling and failure. We tested
whether xanthine oxidase (XO) inhibition could decrease myocardial oxidative stress and …

Background—Accumulating evidence suggests a critical role for increased reactive oxygen
species (ROS) production in left ventricular (LV) remodeling and dysfunction after …

Oxidative stress is a hallmark of systemic illnesses, including heart failure. Nevertheless, the
overall importance of radical production in the heart remains conjectural; is it merely a …

The xanthine oxidase pathway has been proposed as a source ofoxygen-derived free
radicals in ischemic and reperfused myocardium. A spectrophotometric assay was …

BACKGROUND Evidence supporting the role of xanthine oxidase in myocardial reperfusion
injury is based on studies with pharmacological interventions used to inhibit enzyme …

We hypothesized that chronic xanthine oxidase inhibition (XOI) would have favorable effects
on both ventricular and vascular performance in evolving heart failure (HF), thereby …