[HTML][HTML] Recent advances in understanding amyotrophic lateral sclerosis and emerging therapies

LM Gittings, R Sattler - Faculty reviews, 2020 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is
characterized by degeneration of both upper and lower motor neurons and subsequent …

Therapeutic development in amyotrophic lateral sclerosis

M Bucchia, A Ramirez, V Parente, C Simone… - Clinical …, 2015 - Elsevier
Purpose Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in
adults. It is almost invariably lethal within a few years after the onset of symptoms. No …

Amyotrophic lateral sclerosis: update and new developments

AJ Pratt, ED Getzoff, JJP Perry - Degenerative neurological and …, 2012 - Taylor & Francis
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease. It is
typically characterized by adult-onset degeneration of the upper and lower motor neurons …

Understanding ALS: new therapeutic approaches

A Musarò - The FEBS journal, 2013 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with
motor neuron degeneration, muscle atrophy and paralysis. Although numerous pathological …

Roots to start research in amyotrophic lateral sclerosis: molecular pathways and novel therapeutics for future

D Harikrishnareddy, S Misra, S Upadhyay… - Reviews in the …, 2015 - degruyter.com
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease that rapidly
progresses from mild motor symptoms to severe motor paralysis and premature death. There …

[HTML][HTML] Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation

RJ Mead, N Shan, HJ Reiser, F Marshall… - Nature Reviews Drug …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

[HTML][HTML] Clinical manifestation and management of amyotrophic lateral sclerosis

A Verma - 2021 - europepmc.org
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disease
resulting in death in 2 to 4 years in most cases. There are several clinical subtypes of ALS …

[HTML][HTML] Challenges in the understanding and treatment of amyotrophic lateral sclerosis/motor neuron disease

J Rosenfeld, MJ Strong - Neurotherapeutics, 2015 - Elsevier
With the acceleration in our understanding of ALS and the related motor neuron disease has
come even greater challenges in reconciling all of the proposed pathogenic mechanisms …

[HTML][HTML] Recent advances in amyotrophic lateral sclerosis

N Riva, F Agosta, C Lunetta, M Filippi, A Quattrini - Journal of neurology, 2016 - Springer
ALS is a relentlessly progressive and fatal disease, with no curative therapies available to
date. Symptomatic and palliative care, provided in a multidisciplinary context, still remains …

[PDF][PDF] ALS genetics: gains, losses, and implications for future therapies

G Kim, O Gautier, E Tassoni-Tsuchida, XR Ma… - Neuron, 2020 - cell.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by the loss
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …