Therapeutic progress in amyotrophic lateral sclerosis-beginning to learning

V Kumar, A Islam, MI Hassan, F Ahmad - European Journal of Medicinal …, 2016 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with
motor neuron degeneration, muscle weakness, paralysis and finally death. The proposed …

Advances in treating amyotrophic lateral sclerosis: insights from pathophysiological studies

S Vucic, JD Rothstein, MC Kiernan - Trends in neurosciences, 2014 - cell.com
Amyotrophic lateral sclerosis (ALS) is the most frequently occurring of the neuromuscular
degenerative disorders, with a median survival time of 3–5 years. The pathophysiological …

Genetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research

XW Su, JR Broach, JR Connor, GS Gerhard… - Muscle & …, 2014 - Wiley Online Library
Genetic insights into the pathophysiology of amyotrophic lateral sclerosis (ALS) are
untangling the clinical heterogeneity that may contribute to poor clinical trial outcomes and …

Studying ALS: current approaches, effect on potential treatment strategy

EI Ustyantseva, SP Medvedev, SM Zakian - Mechanisms of Genome …, 2020 - Springer
Amyotrophic lateral sclerosis (ALS) is one of the most common neurodegenerative diseases,
characterized by inevitable progressive paralysis. To date, only two disease modifying …

Molecular and cellular mechanisms affected in ALS

L Le Gall, E Anakor, O Connolly… - Journal of personalized …, 2020 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a terminal late-onset condition characterized by the
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …

Prospects for gene replacement therapies in amyotrophic lateral sclerosis

I Giovannelli, A Higginbottom, J Kirby… - Nature Reviews …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a devastating and incurable neurodegenerative
disease characterized by the progressive loss of upper and lower motor neurons. ALS …

What skeletal muscle has to say in amyotrophic lateral sclerosis: Implications for therapy

R Manzano, JM Toivonen… - British Journal of …, 2021 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is an adult onset disorder characterized by progressive
neuromuscular junction (NMJ) dismantling and degeneration of motor neurons leading to …

Moving forward in clinical trials for ALS: motor neurons lead the way please

B Genç, PH Özdinler - Drug discovery today, 2014 - Elsevier
Amyotrophic lateral sclerosis (ALS) is one of the most complex motor neuron diseases. Even
though scientific discoveries are accelerating with an unprecedented pace, to date more …

[HTML][HTML] State of the art and the dark side of amyotrophic lateral sclerosis

A Musarò - World journal of biological chemistry, 2010 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS) is a disorder that involves the degeneration of motor
neurons, muscle atrophy, and paralysis. In a few familiar forms of ALS, mutations in the …

Clinical diagnosis and management of amyotrophic lateral sclerosis

O Hardiman, LH Van Den Berg… - Nature reviews neurology, 2011 - nature.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that results in
progressive loss of bulbar and limb function. Patients typically die from respiratory failure …