Therapeutic progress in amyotrophic lateral sclerosis-beginning to learning
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with
motor neuron degeneration, muscle weakness, paralysis and finally death. The proposed …
motor neuron degeneration, muscle weakness, paralysis and finally death. The proposed …
Advances in treating amyotrophic lateral sclerosis: insights from pathophysiological studies
Amyotrophic lateral sclerosis (ALS) is the most frequently occurring of the neuromuscular
degenerative disorders, with a median survival time of 3–5 years. The pathophysiological …
degenerative disorders, with a median survival time of 3–5 years. The pathophysiological …
Genetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research
Genetic insights into the pathophysiology of amyotrophic lateral sclerosis (ALS) are
untangling the clinical heterogeneity that may contribute to poor clinical trial outcomes and …
untangling the clinical heterogeneity that may contribute to poor clinical trial outcomes and …
Studying ALS: current approaches, effect on potential treatment strategy
EI Ustyantseva, SP Medvedev, SM Zakian - Mechanisms of Genome …, 2020 - Springer
Amyotrophic lateral sclerosis (ALS) is one of the most common neurodegenerative diseases,
characterized by inevitable progressive paralysis. To date, only two disease modifying …
characterized by inevitable progressive paralysis. To date, only two disease modifying …
Molecular and cellular mechanisms affected in ALS
L Le Gall, E Anakor, O Connolly… - Journal of personalized …, 2020 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a terminal late-onset condition characterized by the
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …
Prospects for gene replacement therapies in amyotrophic lateral sclerosis
I Giovannelli, A Higginbottom, J Kirby… - Nature Reviews …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a devastating and incurable neurodegenerative
disease characterized by the progressive loss of upper and lower motor neurons. ALS …
disease characterized by the progressive loss of upper and lower motor neurons. ALS …
What skeletal muscle has to say in amyotrophic lateral sclerosis: Implications for therapy
R Manzano, JM Toivonen… - British Journal of …, 2021 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is an adult onset disorder characterized by progressive
neuromuscular junction (NMJ) dismantling and degeneration of motor neurons leading to …
neuromuscular junction (NMJ) dismantling and degeneration of motor neurons leading to …
Moving forward in clinical trials for ALS: motor neurons lead the way please
B Genç, PH Özdinler - Drug discovery today, 2014 - Elsevier
Amyotrophic lateral sclerosis (ALS) is one of the most complex motor neuron diseases. Even
though scientific discoveries are accelerating with an unprecedented pace, to date more …
though scientific discoveries are accelerating with an unprecedented pace, to date more …
[HTML][HTML] State of the art and the dark side of amyotrophic lateral sclerosis
A Musarò - World journal of biological chemistry, 2010 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS) is a disorder that involves the degeneration of motor
neurons, muscle atrophy, and paralysis. In a few familiar forms of ALS, mutations in the …
neurons, muscle atrophy, and paralysis. In a few familiar forms of ALS, mutations in the …
Clinical diagnosis and management of amyotrophic lateral sclerosis
O Hardiman, LH Van Den Berg… - Nature reviews neurology, 2011 - nature.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that results in
progressive loss of bulbar and limb function. Patients typically die from respiratory failure …
progressive loss of bulbar and limb function. Patients typically die from respiratory failure …