A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as agonists of …
A Garg, S Shuman, B Schwer - Nucleic acids research, 2020 - academic.oup.com
Fission yeast phosphate homeostasis genes are repressed in phosphate-rich medium by
transcription of upstream lncRNAs that interferes with activation of the flanking mRNA …
transcription of upstream lncRNAs that interferes with activation of the flanking mRNA …
Genetic screen for suppression of transcriptional interference reveals fission yeast 14–3–3 protein Rad24 as an antagonist of precocious Pol2 transcription termination
A Garg, S Shuman, B Schwer - Nucleic Acids Research, 2022 - academic.oup.com
Expression of fission yeast Pho1 acid phosphatase is repressed under phosphate-replete
conditions by transcription of an upstream prt lncRNA that interferes with the pho1 mRNA …
conditions by transcription of an upstream prt lncRNA that interferes with the pho1 mRNA …
Duf89 abets lncRNA control of fission yeast phosphate homeostasis via its antagonism of precocious lncRNA transcription termination
AM Sanchez, A Garg, B Schwer, S Shuman - RNA, 2023 - rnajournal.cshlp.org
Fission yeast phosphate homeostasis gene pho1 is actively repressed during growth in
phosphate-rich medium by transcription in cis of a long noncoding (lnc) RNA from the 5 …
phosphate-rich medium by transcription in cis of a long noncoding (lnc) RNA from the 5 …
Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3′ processing and transcription termination
AM Sanchez, A Garg, S Shuman… - Nucleic acids …, 2019 - academic.oup.com
Fission yeast phosphate acquisition genes pho1, pho84, and tgp1 are repressed in
phosphate-rich medium by transcription of upstream lncRNAs. Here, we show that …
phosphate-rich medium by transcription of upstream lncRNAs. Here, we show that …
Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression …
D Chatterjee, AM Sanchez, Y Goldgur, S Shuman… - Rna, 2016 - rnajournal.cshlp.org
Expression of fission yeast Pho1 acid phosphatase is repressed during growth in phosphate-
rich medium. Repression is mediated by transcription of the prt locus upstream of pho1 to …
rich medium. Repression is mediated by transcription of the prt locus upstream of pho1 to …
RNA polymerase II CTD phospho-sites Ser5 and Ser7 govern phosphate homeostasis in fission yeast
B Schwer, AM Sanchez, S Shuman - RNA, 2015 - rnajournal.cshlp.org
Phosphorylation of the tandem YSPTSPS repeats of the RNA polymerase II CTD inscribes
an informational code that orchestrates eukaryal mRNA synthesis. Here we interrogate the …
an informational code that orchestrates eukaryal mRNA synthesis. Here we interrogate the …
Poly (A) site choice and Pol2 CTD Serine-5 status govern lncRNA control of phosphate-responsive tgp1 gene expression in fission yeast
AM Sanchez, S Shuman, B Schwer - RNA, 2018 - rnajournal.cshlp.org
Expression of fission yeast glycerophosphate transporter Tgp1 is repressed in phosphate-
rich medium and induced during phosphate starvation. Repression is enforced by …
rich medium and induced during phosphate starvation. Repression is enforced by …
Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1
B Schwer, A Garg, A Jacewicz… - Proceedings of the …, 2021 - National Acad Sciences
The system of long noncoding RNA (lncRNA)–mediated transcriptional interference that
represses fission yeast phosphate homoeostasis gene pho1 provides a sensitive readout of …
represses fission yeast phosphate homoeostasis gene pho1 provides a sensitive readout of …
Transcriptional profiling of fission yeast RNA polymerase II CTD mutants
A Garg, AM Sanchez, B Schwer, S Shuman - RNA, 2021 - rnajournal.cshlp.org
The carboxyl-terminal domain (CTD) of RNA polymerase II consists of tandem repeats of
heptapeptide Y1S2P3T4S5P6S7. The CTD recruits proteins that drive or regulate gene …
heptapeptide Y1S2P3T4S5P6S7. The CTD recruits proteins that drive or regulate gene …
Transcriptional interference at tandem lncRNA and protein-coding genes: an emerging theme in regulation of cellular nutrient homeostasis
S Shuman - Nucleic acids research, 2020 - academic.oup.com
Tandem transcription interference occurs when the act of transcription from an upstream
promoter suppresses utilization of a co-oriented downstream promoter. Because eukaryal …
promoter suppresses utilization of a co-oriented downstream promoter. Because eukaryal …