Hyperpolarization techniques significantly enhance the sensitivity of magnetic resonance
(MR) and thus present fascinating new directions for research and applications with in vivo …

Over the last two decades, hyperpolarized 13 C MRI has gained significance in both
preclinical and clinical studies, hereby relying on technologies like PHIP-SAH …

This review will highlight recent advances in hyperpolarized 13C MR spectroscopic imaging,
which can be used to noninvasively interrogate tumor metabolism. After providing an …

Hyperpolarized (HP) carbon 13 (13C) MRI is an emerging molecular imaging method that
allows rapid, noninvasive, and pathway-specific investigation of dynamic metabolic and …

Dynamic nuclear spin polarization (DNP), in which polarization is transferred from electron
to nuclear spins at low temperature and high magnetic field, has a long history, with the first …

Advances in genomics are enabling integration of various-omics to reveal the complexities
underneath carcinogenesis. Multivariate signaling pathways are deregulated and evolve …

Magnetic resonance (MR) is a powerful imaging modality providing high temporal and
spatial resolution of morphological details. The modality is widespread, well accepted, and …

This white paper discusses prospects for advancing hyperpolarization technology to better
understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13 C …

Dynamic nuclear polarization is an emerging technique for increasing the sensitivity of
magnetic resonance imaging and spectroscopy, particularly for low‐γ nuclei. The technique …

Metabolic reprogramming is an important hallmark of cancer. Alterations in many metabolic
pathways support the requirement for cellular building blocks that are essential for cancer …