Since reaching the clinic, magnetic resonance imaging (MRI) has become an irreplaceable
radiological tool because of the macroscopic information it provides across almost all organs …

Hyperpolarized 13C MR spectroscopic imaging can detect not only the uptake of the pre‐
polarized molecule but also its metabolic products in vivo, thus providing a powerful new …

Hyperpolarized MRI with 13C‐labeled metabolites has enabled metabolic imaging of tumors
in vivo. The heterogeneous nature of tumors and the limited lifetime of the hyperpolarization …

Magnetic resonance (MR)‐based hyperpolarized (HP) 13C metabolic imaging is under
active pursuit as a new clinical diagnostic method for cancer detection, grading, and …

MRI with hyperpolarized carbon‐13 agents has created a new type of noninvasive, in vivo
metabolic imaging that can be applied in cell, animal, and human studies. The use of 13C …

Glucose metabolism in tumours is reprogrammed away from oxidative metabolism, even in
the presence of oxygen. Non-invasive imaging techniques can probe these alterations in …

Hyperpolarized metabolic imaging is a growing field that has provided a new tool for
analyzing metabolism, particularly in cancer. Given the short life times of the hyperpolarized …

Editorial Dissolution dynamic nuclear polarization (dDNP) development, which involves
rapidly dissolving hyperpolarized compounds mixed with an electron paramagnetic agent …

Purpose Although 1H spin coupling is generally avoided in probes for hyperpolarized (HP)
13C MRI, enzymatic transformations of biological interest can introduce large 13C‐1H …

Introduction: The use of hyperpolarized molecules allows one to obtain information about
metabolism in both cells and animals; such a task represents a tremendous advancement …