pH is a fundamental physiological parameter that is tightly controlled by endogenous
buffers. The acid–base balance is altered in many disease states, such as inflammation …

Object The PASADENA method has achieved hyperpolarization of 16–20%(exceeding
40,000-fold signal enhancement at 4.7 T), in liquid samples of biological molecules relevant …

Magnetic resonance imaging (MRI) is the only imaging modality that can deliver information
about the molecular structure of an injected compound. Unfortunately, MRI has a relatively …

Purpose In contrast to conventional MR, signal‐to‐noise ratio (SNR) is not linearly
dependent on field strength in hyperpolarized MR, as polarization is generated outside the …

Recent developments in NMR hyperpolarization have enabled a wide array of new in vivo
molecular imaging modalities, ranging from functional imaging of the lungs to metabolic …

Magnetic resonance spectroscopy (MRS) can be performed in vivo using commercial MRI
systems to obtain biochemical information about tissues and cancers. Applications in brain …

Purpose Metabolic imaging with hyperpolarized 13C‐labeled cell substrates is a promising
technique for imaging tissue metabolism in vivo. However, the transient nature of the …

Hyperpolarized NMR is a promising technique for non‐invasive imaging of tissue
metabolism in vivo. However, the pathways that can be studied are limited by the fast T1 …

In the past decade, hyperpolarized (HP) contrast agents have been under active
development for MRI applications to address the twin challenges of functional and …

Purpose To develop symmetric echo planar imaging (EPI) and a reference scan framework
for hyperpolarized 13C metabolic imaging. Methods Symmetric, ramp‐sampled EPI with …