Chronic neuropathic pain precipitates a complex range of affective and behavioural
disturbances that differ markedly between individuals. While the reasons for differences in …

There is a paucity of data on the role of microglia and neuroinflammatory processes in the
association between chronic pain and depression. The current study examined the effect of …

LETTER TO EDITOR The recent article by Wang et al.(2012) in the Journal provided for
highly interesting reading. Recent data suggest that minocycline has significant …

Substantial evidence indicates involvement of microglia/macrophages in chronic
neuropathic pain. However, the temporal-spatial features of microglial/macrophage …

The research on sex differences in nociception and antinociception as well as sex and
gender differences in pain and analgesia is a maturing field. There is a vast literature …

Abstract The Center for Disease Control and Prevention estimates that 75% of reported
cases of traumatic brain injury (TBI) are mild, where chronic pain and depression are 2 of the …

Background Minocycline is a clinically available synthetic tetracycline derivative with anti-
inflammatory and antibiotic properties. The majority of studies show that minocycline can …

In the present study, intraperitoneal administration of minocycline attenuated enhancing
nociceptive behaviors in those rats receiving dual formalin injections (5% formalin followed …

Glia, particularly astrocytes and microglia, are known to play an important role in central
sensitization and are strongly implicated in the exaggerated pain states. In the present study …

Minocycline is a broad-spectrum tetracycline antibiotic with multiple actions, including anti-
inflammatory and neuroprotective effects, that was proposed as novel treatment for several …