Nasopharyngeal carcinoma (NPC) is a particular entity of head neck cancer that is generally
regarded as a genetic disease with diverse intertumor and intratumor heterogeneity. This …

The evolution of the tumor microenvironment (TME) is a cancer-dependent and dynamic
process. The TME is often a complex ecosystem with immunosuppressive and tumor …

A small but growing number of people are finding interesting parallels between ecosystems
as studied by ecologists (think of a savannah or the Amazon rainforest or a coral reef) and …

Cancer cells can be conceived as “living organisms” interacting with cellular or non‐cellular
components in the host internal environment, not only the local tumor microenvironment but …

Abstract Of the~ 129,079 new cases of nasopharyngeal carcinoma (NPC) and 72,987
associated deaths estimated for 2018, the majority will be geographically localized to South …

Ecological fitness is the ability of individuals in a population to survive and reproduce.
Individuals with increased fitness are better equipped to withstand the selective pressures of …

The role of genetic mutations in cancer is indisputable: They are a key source of tumor
heterogeneity and drive its evolution to malignancy. But, the success of these new mutant …

We propose that there is an opportunity to devise new cancer therapies based on the
recognition that tumors have properties of ecological systems. Traditionally, localized …

The diverse malignant, stromal, and immune cells in tumors affect growth, metastasis, and
response to therapy. We profiled transcriptomes of∼ 6,000 single cells from 18 head and …

The tumor microenvironment (TME) of head and neck squamous cell carcinoma (HNSCC) is
comprised of cancer-associated fibroblasts (CAFs), immune cells, and other supporting …