The Senescence Program is Reduced in Proteasome Inhibitor Bortezomib-Resistant PC3 Prostate Cancer Cell Line
Objective: Senescence may act as an antitumor mechanism by preventing the proliferation
of cancer cells. Here we investigated the hypothesis that PC3 prostate cancer cells resistant …
of cancer cells. Here we investigated the hypothesis that PC3 prostate cancer cells resistant …
Molecular analysis of cell survival and death pathways in the proteasome inhibitor bortezomib-resistant PC3 prostate cancer cell line
The ubiquitin–proteasome pathway is an important protein quality control system involved in
intracellular homeostasis. To achieve intracellular homeostasis, proteins that are misfolded …
intracellular homeostasis. To achieve intracellular homeostasis, proteins that are misfolded …
The proteasome inhibitor bortezomib stabilizes a novel active form of p53 in human LNCaP-Pro5 prostate cancer cells
SA Williams, DJ McConkey - Cancer research, 2003 - AACR
Advanced prostate cancer is resistant to current therapeutic strategies. Bortezomib (Velcade;
previously called PS-341) is a potent and specific inhibitor of the 26S proteasome that is …
previously called PS-341) is a potent and specific inhibitor of the 26S proteasome that is …
[HTML][HTML] CVT-313
E Kanbur, AT Baykal, A Yerlikaya - nur77signal.com
The ubiquitin–proteasome pathway is an important protein quality control system involved in
intracellular homeostasis. To achieve intracellular homeostasis, proteins that are misfolded …
intracellular homeostasis. To achieve intracellular homeostasis, proteins that are misfolded …
Therapy-induced senescence is reversible in vitro and in vivo
While cellular senescence has long been recognized as an irreversible form of growth
arrest, evidence in the literature has suggested that subpopulations of senescent tumor cells …
arrest, evidence in the literature has suggested that subpopulations of senescent tumor cells …
Proteasome inhibitor bortezomib increases radiation sensitivity in androgen independent human prostate cancer cells
OBJECTIVES: To investigate the effects of a strong proteasome inhibitor, bortezomib alone
or in combination with radiotherapy on androgen-independent DU145 human prostate …
or in combination with radiotherapy on androgen-independent DU145 human prostate …
Sensitivity of neoplastic cells to senescence unveiled under standard cell culture conditions
J Zieba, M Ksiazkiewcz, K Janik… - Anticancer …, 2015 - ar.iiarjournals.org
Background: Cancer cells are typically defined as infinitely proliferating, whereas normal
cells (except stem cells) are considered as being programmed to become senescent. Our …
cells (except stem cells) are considered as being programmed to become senescent. Our …
The identification of senescence-specific genes during the induction of senescence in prostate cancer cells
SR Schwarze, VX Fu, JA Desotelle, ML Kenowski… - Neoplasia, 2005 - Elsevier
Classic mechanisms of tumor response to chemotherapy include apoptosis, mitotic
catastrophe. Recent studies have suggested that cellular senescence, a terminal …
catastrophe. Recent studies have suggested that cellular senescence, a terminal …
P53 and the proteasome regulate androgen receptor activity
NV Guseva, OW Rokhlin, RA Glover… - Cancer Biology & …, 2012 - Taylor & Francis
Mutual regulation of expression between p53 and AR has been reported. To further
investigate the role of p53 in the regulation of AR expression, an ARE-Luciferase vector was …
investigate the role of p53 in the regulation of AR expression, an ARE-Luciferase vector was …
[HTML][HTML] Diversity of the senescence phenotype of cancer cells treated with chemotherapeutic agents
A Bojko, J Czarnecka-Herok, A Charzynska… - Cells, 2019 - mdpi.com
It is acknowledged that cancer cells are able to undergo senescence in response to
clinically used chemotherapeutics. Moreover, recent years have provided evidence that …
clinically used chemotherapeutics. Moreover, recent years have provided evidence that …