Siglec‐7 is a sialic acid binding receptor with inhibitory potential, expressed on human NK
cells and monocytes. It has an unusual binding preference for α2, 8‐linked disialic acids …

Abstract Siglec-7 is a CD33-related sialic acid-binding Ig-like lectin expressed strongly on
NK cells, where it can function as an inhibitory receptor. Its sialic acid-binding activity on NK …

GD3, a ganglioside expressed on human melanoma, can be recognized by the humoral
immune system. In this paper, we demonstrate that immunizing mice with the human …

Siglec-7 is a human CD33-like siglec, and is localised predominantly on human natural
killer (NK) cells and monocytes. Siglec-7 is considered to function as an immunoreceptor in …

Gangliosides have diverse biological functions including modulation of immune system
response. These molecules are differentially expressed on malignant cells compared with …

Gangliosides are ubiquitous membrane-associated glycosphingolipids, which are involved
in cell growth and differentiation. Most tumor cells synthesize and shed large amounts of …

Here we characterize Siglec-10 as a new member of the Siglec family of sialic acid-binding
Ig-like lectins. A full-length cDNA was isolated from a human spleen library and the …

The siglecs are a group of mammalian sialic acid binding receptors expressed
predominantly in the immune system. The CD33-related siglecs show complex recognition …

In renal cell carcinoma (RCC), the presence of higher gangliosides correlates with
systematic metastasis. Disialosyl globopentaosylceramide (DSGb5) was identified …

We previously elucidated an important role for gangliosides in renal cell carcinoma–
mediated T lymphocyte apoptosis, although the mechanism by which they mediated …