T cells are vital for adaptive immune responses that protect against pathogens and cancers.
The T cell receptor (TCR)–CD3 complex comprises a diverse αβ TCR heterodimer in …

T cells generate adaptive immune responses mediated by the T cell receptor (TCR)–CD3
complex comprising an αβ TCR heterodimer noncovalently associated with three CD3 …

MHC-encoded molecules govern immune responses by presenting antigenic peptides to T-
cell receptors (TCRs). Several crystal structures of TCR–pMHC (peptide–MHC) complexes …

T cells use their T-cell receptors (TCRs) to scan other cells for antigenic peptides presented
by MHC molecules (pMHC). If a TCR encounters a pMHC, it can trigger a signalling pathway …

To better understand TCR discrimination of multiple ligands, we have analyzed the crystal
structures of two Hb peptide/IE k complexes that differ by only a single amino acid …

Helper T lymphocytes play a critical role in immune system activation following recognition
of MHC class II-bound peptide ligands (pMHCII). These CD4 T cells stimulate B cell antibody …

T cell receptors (TCRs) recognize peptides presented by MHC molecules (pMHC) on an
antigen-presenting cell (APC) to discriminate foreign from self-antigens and initiate adaptive …

TCR-signaling strength generally correlates with peptide-MHC binding affinity; however,
exceptions exist. We find high-affinity, yet non-stimulatory, interactions occur with high …

αβ T-cell receptors (TCRs) engage antigens using complementarity-determining region
(CDR) loops that are either germ line-encoded (CDR1 and CDR2) or somatically rearranged …

MHC-encoded molecules govern adaptive immune responses by presenting peptides to T
cell receptors (TCRs). Based on TCR–MHC crystal structures, we revisit the extent of TCR …