T cell receptor (TCR) engagement of peptide-major histocompatibility complex (pMHC) is
essential to adaptive immunity, but it is unknown whether TCR signaling responses are …

T cell receptor (TCR) recognition of peptide-MHC (pMHC) is central to the cellular immune
response. A large database of TCR–pMHC structures is needed to reveal general structural …

The molecular interactions between the CD8 co-receptor dependent N15 and N26 T cell
receptors (TCRs) and their common ligand, the vesicular stomatitis virus octapeptide (VSV8) …

A 1983 Immunology Today rostrum hypothesized that each T cell has two recognition units:
a T cell receptor (TCR) complex, which binds antigen associated with a polymorphic region …

In the last four years, the atomic structures of more than molecules the peptide, usually
derived from extracellular a half-dozen of the intercellular recognition complexes, antigens …

A6 and B7 are two αβ T cell receptors (TCRs) that recognize the Tax peptide presented by
the class I major histocompatibility molecule HLA-A2 (Tax/HLA-A2). Despite the fact that the …

Interactions between a T cell receptor (TCR) and a peptide-major histocompatibility complex
(pMHC) ligand are typically mediated by noncovalent bonds. By studying T cells expressing …

We report the creation of TCR partial agonists by the novel approach of manipulating the
interaction between immunogenic peptide and MHC. Amino acids at MHC anchor positions …

T cell receptors (TCRs) orchestrate cellular immunity by recognizing peptides presented by
a range of major histocompatibility complex (MHC) proteins. Naturally occurring TCRs bind …

TCR recognition of MHC/peptide complexes directs many aspects of T cell biology, including
thymic selection, survival of naı̈ve T cells and differentiation into effector and memory T …