T cells are critical for protective immune responses to pathogens and tumors. The T-cell
receptor (TCR)–CD3 complex is composed of a diverse αβ TCR heterodimer noncovalently …

The specificity of T cell-mediated immune responses is primarily determined by the
interaction between the T cell receptor (TCR) and the antigenic peptide presented by the …

More than a decade after the first description of the primary structure of a T‐cell antigen
receptor (TCR), the recent determination of the crystal structure of several unliganded TCR …

Self-reactive T cells that escape elimination in the thymus can cause autoimmune pathology,
and it is therefore important to understand the structural mechanisms of self-antigen …

T‐cell receptors (TCR s) can productively interact with many different peptides bound within
the MHC binding groove. This property varies with the level of cross‐reactivity of TCR s; …

T cell receptor (TCR) recognition of antigenic peptides bound and presented by class I major
histocompatibility complex (MHC) proteins underlies the cytotoxic immune response to …

The third complementarity-determining regions (CDR3s) of antibodies and T cell receptors
(TCRs) have been shown to play a major role in antigen binding and specificity. Consistent …

Recent studies have identified peptide–MHC molecule ligands of αβ T-cell receptors with
properties apparently distinct from classical agonists. These complexes, which are slight …

Antigen recognition of peptide-major histocompatibility complexes (pMHCs) by T cells, a key
step in initiating adaptive immune responses, is performed by the T cell receptor (TCR) …

Although conformational changes in TCRs and peptide Ags presented by MHC protein
(pMHC) molecules often occur upon binding, their relationship to intrinsic flexibility and role …