CD4+ and CD8+ αβ T cell antigen recognition is determined by the interaction between the
TCR Complementarity Determining Region (CDR) loops and the peptide-presenting MHC …

Interactions between the T cell receptor and cognate peptide–MHC are crucial initiating
events in the adaptive immune response. These binding events are highly specific yet occur …

Crystal structures of 11 complexes of TCRs with peptide/MHC (pMHC), that represent 6
independent TCRs, constitute the current structural database for deriving general insights …

The major defense system against microbial pathogens in vertebrates is the adaptive
immune response and represents an effective mechanism in cancer surveillance. T cells …

Over the past two decades, structural biology has shown how T‐cell receptors engage
peptide/major histocompatibility complex (MHC) complexes and provided insight into the …

Antigen-dependent activation of T lymphocytes requires T cell receptor (TCR)-mediated
recognition of specific peptides, together with the MHC molecules to which they are bound …

The potency of a T cell is determined in large part by two interactions, binding of a cognate
peptide to the MHC, and binding of the T cell receptor (TCR) to this pepMHC. Various …

Complementarity-determining regions (CDRs) of αβ T-cell receptors (TCRs) sense peptide-
bound MHC (pMHC) complexes via chemical interactions, thereby mediating antigen …

The coreceptor CD8αβ can greatly promote activation of T cells by strengthening T-cell
receptor (TCR) binding to cognate peptide-MHC complexes (pMHC) on antigen presenting …

Despite major advances in T cell receptor (TCR) biology and structure, how peptide–MHC
complex (pMHC) ligands trigger αβ TCR activation remains unresolved. Two views exist …