T cell receptor cross-reactivity allows a fixed T cell repertoire to respond to a much larger
universe of potential antigens. Recent work has emphasized the importance of peptide …

The structural basis of antigen recognition in cellular immunity has been elucidated through
the determination of crystal structures of major histocompatibility complex (MHC) molecules …

T cells use the αβ TCR to bind peptides presented by MHC proteins (pMHC) on APCs.
Formation of a TCR–pMHC complex initiates T cell signaling via a poorly understood …

The structural basis of T cell activation through the T cell receptor is still a major unresolved
issue in T cell biology. The wealth of information on the generation and structure of T cell …

T cell receptors (TCRs) exhibit genetic and structural diversity similar to antibodies, but they
have binding affinities that are several orders of magnitude lower. It has been suggested that …

T cells are the master regulators of immune system function, continually walking the
biological tightrope between adequate host defence and accidental host pathology …

αβ T cell receptors (TCRs) are genetically restricted to corecognize peptide antigens bound
to self-major histocompatibility complex (pMHC) molecules; however, the basis for this MHC …

▪ Abstract Exciting breakthroughs in the last two years have begun to elucidate the structural
basis of cellular immune recognition. Crystal structures have been determined for full-length …

Background: T-cells are activated by engagement of their clonotypic cell surface receptors
with peptide complexes of major histocompatibility complex (MHC) proteins, in a poorly …

TCRs recognize cognate pMHCs to initiate T cell signaling and adaptive immunity.
Mechanical force strengthens TCR-pMHC interactions to elicit agonist-specific catch bonds …