Abstract αβ T cells respond to peptide epitopes presented by major histocompatibility
complex (MHC) molecules. The role of T cell receptor (TCR) germline complementarity …

T cells are a critical part of the adaptive immune system that are able to distinguish between
healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T …

The molecular mechanism through which the interaction of a clonotypic αβ T-cell receptor
(TCR) with a peptide-loaded major histocompatibility complex (p/MHC) leads to T-cell …

Adaptive immunity depends on specific recognition by a T-cell receptor (TCR) of an
antigenic peptide bound to a major histocompatibility complex (pMHC) molecule on an …

Foreign antigens are presented by antigen-presenting cells in the presence of abundant
endogenous peptides that are nonstimulatory to the T cell. In mouse T cells, endogenous …

Significant progress has been made on several long-standing issues regarding T-cell
receptor mediated recognition of antigen-MHC complexes. For one, early data suggest that …

The viral peptides presentation by major histocompatibility complex class I (MHC I)
molecules play a pivotal role in T-cell recognition and the subsequent virus clearance. This …

Abstract αβ T cell receptors (TCRs) recognize peptides presented by major
histocompatibility complex (MHC) proteins using multiple complementarity-determining …

In cellular immunity, clonally distributed T cell receptors (TCRs) engage complexes of
peptides bound to major histocompatibility complex proteins (pMHCs). In the interactions of …

Successful immunity requires that a limited pool of αβ T-cell receptors (TCRs) provide cover
for a vast number of potential foreign peptide antigens presented by 'self'major …