Limited plasticity in T cell recognition of modified T cell receptor contact residues in MHC class II bound peptides
EC de Haan, JPA Wagenaar-Hilbers, RMJ Liskamp… - Molecular …, 2005 - Elsevier
The balance between specific and degenerate T cell recognition of MHC class II bound
peptides is crucial for T cell repertoire selection, and holds important implications for …
peptides is crucial for T cell repertoire selection, and holds important implications for …
MHC class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs
L Wooldridge, M Clement, A Lissina… - The Journal of …, 2010 - journals.aai.org
CD8+ CTLs are essential for effective immune defense against intracellular microbes and
neoplasia. CTLs recognize short peptide fragments presented in association with MHC class …
neoplasia. CTLs recognize short peptide fragments presented in association with MHC class …
[HTML][HTML] Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time
T cell receptor (TCR) binding to diverse peptide-major histocompatibility complex (pMHC)
ligands results in various degrees of T cell activation. Here we analyze which binding …
ligands results in various degrees of T cell activation. Here we analyze which binding …
Evolutionarily conserved amino acids that control TCR-MHC interaction
The rules for the conserved reaction of αβ T cell receptors (TCRs) with major
histocompatibility complex (MHC) proteins plus peptides are poorly understood, probably …
histocompatibility complex (MHC) proteins plus peptides are poorly understood, probably …
Coevolution of T‐cell receptors with MHC and non‐MHC ligands
The structure and amino acid diversity of the T‐cell receptor (TCR), similar in nature to that of
Fab portions of antibodies, would suggest that these proteins have a nearly infinite capacity …
Fab portions of antibodies, would suggest that these proteins have a nearly infinite capacity …
The T cell receptor's α-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation
M Mallaun, D Naeher, MA Daniels… - The Journal of …, 2008 - journals.aai.org
The CD8 coreceptor contributes to the recognition of peptide-MHC (pMHC) ligands by
stabilizing the TCR-pMHC interaction and enabling efficient signaling initiation. It is unclear …
stabilizing the TCR-pMHC interaction and enabling efficient signaling initiation. It is unclear …
Previously hidden dynamics at the TCR–peptide–MHC interface revealed
A structural characterization of the interaction between αβ TCRs and cognate peptide–MHC
(pMHC) is central to understanding adaptive T cell–mediated immunity. X-ray …
(pMHC) is central to understanding adaptive T cell–mediated immunity. X-ray …
A high affinity T cell receptor?
S Alberti - Immunology and cell biology, 1996 - Wiley Online Library
T cell receptors (TCR) have a low affinity for the MHC and the presented peptides
(MHCpep). The low affinity of the TCR is crucial in T cell recognition and activation …
(MHCpep). The low affinity of the TCR is crucial in T cell recognition and activation …
A role for “self” in T-cell activation
M Krogsgaard, J Juang, MM Davis - Seminars in immunology, 2007 - Elsevier
The mechanisms by which αβ T-cells are selected in the thymus and then recognize peptide
MHC (pMHC) complexes in the periphery remain an enigma. Recent work particularly with …
MHC (pMHC) complexes in the periphery remain an enigma. Recent work particularly with …
[HTML][HTML] A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers
Major histocompatibility complex class I (MHCI) and MHCII proteins differ in structure and
sequence. To understand how T cell receptors (TCRs) can use the same set of variable …
sequence. To understand how T cell receptors (TCRs) can use the same set of variable …