Background Survival of patients with cT 4 esophageal cancer is dismal. Although the optimal
treatment strategy remains to be established, two treatment options are available for cT 4 …

The outcome of patients with T4 esophageal cancer, defined as a tumor that invades
neighboring structures (eg, aorta, trachea, bronchus, and lung), is extremely poor. Despite …

Background We report the long-term results as primary endpoint in a multicentre
randomized prospective Phase 2 trial which compared chemoradiotherapy (CRT) and triplet …

Although no consensus is available on the treatment of esophageal squamous cell
carcinoma (ESCC) invading adjacent organs (T4), establishing effective induction …

Objective: We conducted a multicenter randomized prospective phase 2 trial of
chemoradiotherapy (CRT) versus chemotherapy (CT) as initial induction therapy for …

Background Treatment of cT4b esophageal carcinoma usually consists of definitive
chemoradiotherapy (dCRT). However, outcome after dCRT in these patients is poor …

Purpose The management of cT4b thoracic esophageal cancer (EC) is challenging. The
optimal treatment remains unclear, and prospective or large-scale retrospective reports on …

Background Definitive chemoradiotherapy (dCRT) for esophageal squamous cell carcinoma
(ESCC) is a potentially curative treatment modality, even for patients with unresectable T4 …

Background Survival outcomes of patients with cT4 esophageal squamous cell carcinoma
(ESCC) remain extremely poor. We aimed to investigate long-term outcomes and identify …

The prognosis of patients with T4 esophageal carcinoma is poor, and thus an effective
treatment needs to be established. The present study assessed the effect of …