Abstract Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood
flow that plays an important role in blood pressure (BP) elevation in some models of …

Endothelin-1 (ET-1) is overexpressed in the vascular wall in certain models of experimental
hypertension: deoxycorticosterone acetate salt–treated rats, deoxycorticosterone acetate …

Abstract Endothelin-1 (ET-1) was first characterized as a potent vasoconstrictor and is
overexpressed in the vasculature in different models of hypertension, such as …

Endothelins are powerful vasoconstrictor peptides that also play numerous other functions in
many different organs. Endothelin-1 (ET-1) is the most abundant and important of this family …

The endothelins are a family of endothelium-derived peptides that possess characteristically
sustained vasoconstrictor properties. Endothelin-1 appears to be the predominant member …

The endothelins (ET) are potent 21-amino-acid vasoconstrictor peptides produced in many
different tissues, particularly in the endothelium of blood vessels. ET-1 is the main …

Endothelins are a family of peptides, which comprises endothelin-1 (ET-1), endothelin-2 (ET-
2) and endothelin-3 (ET-3), each containing 21 amino-acids. ET-1 is a peptide secreted …

We previously showed that endothelin-1 expression was increased in vascular endothelium
of deoxycorticosterone acetate–salt hypertensive rats, whereas in spontaneously …

In 1988, Yanagisawa et al. reported the presence of a potent peptide from the supernatant of
porcine endothelial cells. This was later named endothelin‐1 (ET‐1) and was found to …

To investigate the possible involvement of endothelin-1 (ET-1), an endothelium-derived
potent vasoconstrictor peptide, in the pathophysiology of hypertension, plasma ET-1 levels …