The endothelins are a family of 21–amino acid peptides that are powerful vasoconstrictors.
They may also induce vascular hypertrophy. These peptides may participate through these …

Background: This study compares plasma endothelin-1 (ET-1) levels in patients with
diabetes mellitus or hypertension with healthy controls, and investigates whether ET-1 levels …

To investigate the potential pathogenic role of endothelin in blood pressure elevation and
vascular hypertrophy in renovascular hypertensive rats, which present twofold elevations in …

Nitric oxide (NO) and endothelin (ET) produced in endothelial cells are leading molecules
which regulate vascular function. Failure of the physiological balance between these two …

The discovery of endothelin two decades ago has now evolved into an intricate vascular
endothelin (ET) system. Several ET isoforms, receptors, signaling pathways, agonists …

Abstract Endothelin (ET)-1 is a potent vasoconstrictor peptide originally isolated from
endothelial cells. Its production is stimulated in a variety of different cell types under the …

Abstract Endothelin (ET)-1 is a potent vasoconstrictor peptide which is also endowed with
hypertrophic and mitogenic properties. Enhanced ET-1 gene expression in blood vessels of …

Endothelin was isolated and identified in 1988 by Yanagisawa et al. The endothelin family
consists of 21 amino acid isoforms endothelin-1, endothelin-2 and endothelin-3. Endothelin …

Endothelins are ubiquitously produced 21-amino-acid peptides that were discovered as an
endothelial product and may play important roles in cardiovascular physiology and …

The endothelium produces a variety of substances that play important roles in regulation of
the circulation and vascular wall homeostasis. The control of blood vessel wall homeostasis …