Endothelin (ET) 1 is a potent vasoconstrictor peptide produced by vascular endothelial cells
and implicated in various pathophysiologic states involving abnormal vascular tone …

Endothelin is the most potent mammalian vasoconstrictor yet discovered. Its three isoforms
play leading roles in regulating vascular tone and causing mitogenesis. The isoforms bind to …

Atherosclerotic vascular disease remains the single most prevalent cause of death and
morbidity in the western world. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide that …

Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide produced in the endothelium of
blood vessels that may play an important role in the control of local blood flow and could be …

Endothelin (ET) is a potent vasoconstrictive peptide initially found in the conditioned medium
of cultured endothelial cells (1). It comprises 21 amino acid residues including four cysteine …

The normal functional state of the vasculature and the events leading to the development of
significant arterial disease involve the interaction of important vasoactive substances, which …

▪ Abstract In this article, we review the basic pharmacological and biochemical features of
endothelin and the pathophysiological roles of endothelin in cardiovascular diseases …

Abstract Endothelin-1 (ET-1), a 21-amino acid peptide, was initially identified in 1988 as a
potent vasoconstrictor and pressor substance isolated from the culture supernatant of …

The discovery in 1988 of endothelin-1 (ET-1) by Yanagisawa and colleagues in Japan
represented a landmark in the field of cardiovascular research. 1 A combination of molecular …

The 21-amino acid peptide endothelin-1 (ET-1) is the predominant isoform of the endothelin
peptide family, which includes ET-2, ET-3, and ET-4. It exerts various biological effects …