Endothelin, a recently discovered peptide produced by endothelial cells, contracts vascular
strips in vitro with greater potency than any previously known vasoconstrictor. Infusions of …

The ETs (endothelins) comprise a family of three 21-amino-acid peptides (ET-1, ET-2 and
ET-3) and 31-amino-acid ETs (ET-11–31, ET-21–31 and ET-31–31). ET-1 is synthesized …

Since its identification as an endothelial cell-derived vasoconstrictor peptide in 1988,
endothelin-1, the predominant member of the endothelin peptide family, has received …

Discovered in 1987 as a potent endothelial cell–derived vasoconstrictor peptide, endothelin-
1 (ET-1), the predominant member of the endothelin peptide family, is now recognized as a …

Endothelin-1 (ET-1) is a potent vasoconstrictive peptide produced by endothelial cells of
blood vessels. This peptide has quite a unique structure and pharmacological properties. ET …

Abstract Endothelin (ET)-1 derived from endothelial cells has a much more important role in
cardiovascular system regulation than the ET-2 and ET-3 isoforms. Numerous lines of …

Endothelins are powerful vasoconstrictor peptides that also play numerous other roles. The
endothelin (ET) family consists of three peptides produced by a variety of tissues. Endothelin …

OBJECTIVE We sought to assess the activity of endogenous endothelin-1 (ET-1) in
hypercholesterolemic patients using antagonists of ET-1 receptors. BACKGROUND …

The incidence of chronic kidney disease (CKD) is increasing worldwide. Cardiovascular
disease (CVD) is strongly associated with CKD and constitutes one of its major causes of …

The endothelin family of peptides are extremely potent endogenous vasoconstrictor and
pressor agents. Of the 3 isoforms, endothelin-1 is the major isoform produced by the …