Endothelins build a peptide family composed of three isoforms, each of them containing 21
amino acids. Endothelin-1 is the isoform mainly responsible for any cardiovascular action …

Background Endothelins are potent vasoconstrictors, and may also act as mitogens and
hypertrophic agents. Expression of a member of this family of peptides, endothelin-1, is …

It is now two decades since it was demonstrated that ET-1 is one of the most powerful
vasoconstrictors in biology. ET-1 mediates its effects through two membrane G-protein …

The prevalence of essential hypertension in blacks is much higher than that in whites. In
addition, the pathogenesis of hypertension appears to be different in black patients. For …

Since the discovery of endothelin-1 as the most potent endothelial-derived vasoconstrictor/
mitogenic peptide a decade ago, considerable evidence has implicated this peptide in …

We measured plasma concentrations of immunoreactive endothelin-1 (irET-1) in the
prehypertensive and hypertensive phases in spontaneously hypertensive rats (SHR) and in …

The endothelin (ET) system consists of three peptide ligands (ET-1, ET-2 and ET-3) and two
G-protein-coupled receptors, ETA and ETB. In the cardiovascular system, ETs, particularly …

Experiments in cultured vascular smooth muscle cells have shown that angiotensin II (Ang II)
stimulates expression of endothelin-1. We sought to examine role of endothelin-1 in the …

Abstract Endothelin (ET)‐1 is a potent vasoconstrictor peptide with pro‐inflammatory,
mitogenic, and pro‐fibrotic properties that is closely involved in both normal renal physiology …

Endothelin-1 (ET-1) is a 21-amino acid peptide that potently modulates renal function. ET-1
is produced by, and binds to, most renal cell types. ET-1 exerts a wide range of biologic …