Endothelin-1 (ET-1) is a multifunctional hormone which regulates the physiology of the
cardiovascular and renal systems. ET-1 modulates cardiac contractility, systemic and renal …

Effects of endothelin-1 on renal function in humans: Implications for physiology and
pathophysiology. Elevated levels of the vasocontrictor peptide endothelin-1 have been …

Apart from the initially described vasoconstriction, endothelins have been shown to cause a
variety of biological activities in non-vascular tissues. A rapidly growing body of data …

Circulating plasma levels of endothelin-1 and related peptides generated during the
synthesis of endothelin-1 from its precursor molecule pre-proendothelin-1 have been widely …

BACKGROUND Endothelin is an endothelium-derived peptide that produces sustained
contraction of arterial and venous smooth muscle in vitro. Several studies have established …

Background—Hypertensive patients have both impaired endothelium-dependent
vasodilation and increased activity of the endothelin (ET-1) system, which participate in their …

Endothelin-1 (ET-1) is a vasoconstrictor secreted by endothelial cells, which acts as the
natural counterpart of the vasodilator nitric oxide (NO). ET-1 contributes to vascular tone and …

Endothelin, a potent vasoconstrictor peptide synthesized by the vascular smooth muscle
endothelium, was chronically infused into male Sprague-Dawley rats to determine whether a …

Increased evidence has shown that endothelin‐1 (ET‐1) derived from the arterial cells is
involved in the development of atherosclerosis. ET‐1 and ET receptors are upregulated in …

Background Some patients with typical angina and electrocardiographic evidence of
ischemia have normal coronary angiograms. These patients have a reduced coronary flow …