Cardiovascular disease is a major contributor to global morbidity and mortality and is the
common end point of many chronic diseases. The endothelins comprise three structurally …

Background—The participation of endothelin-1 (ET-1) in the control of vascular tone in
humans has been questioned, on the basis of the finding of subthreshold immunoreactive …

Endothelin (ET) 1 is a potent vasoactive peptide implicated in the pathogenesis of
hypertension and renal disease. The aim of the current study was to test the hypotheses that …

Endothelins (ETs) are 21-amino-acid peptides produced in many cells and tissues. The
vascular ET system is represented mainly by ET-1 produced in endothelial cells. PreproET-1 …

We investigated the possible role of endothelin in the increased vasoconstrictor tone of
hypertensive patients using antagonists of endothelin receptors. Forearm blood flow (FBF) …

Urinary excretion rate of endothelin-1 in patients with essential hypertension and salt
sensitivity. To assess the possible role of ET-1 in the pathogenesis of hypertension and salt …

Abstract Endothelin-1 (ET-1) is a potent vasoconstrictor peptide implicated in a number of
human diseases including atherosclerosis. ET-1 binds to two distinct G protein-coupled …

Effects of endothelin-3 on the secretion of endothelin-1 and other endothelium-derived
substances were investigated in cultured human umbilical vein endothelial cells. The …

Abstract A newly synthesized ET A-selective antagonist, BQ-123, was examined with respect
to its anti-endothelin (ET) action in vitro and in vivo and its effect on blood pressure in Wistar …

Since the discovery of the most potent vasoconstrictor peptide, endothelin, in 1988,
explosive investigations have rapidly clarified much of the basic pharmacological …