Cell transplantation is a useful therapy for treating peripheral nerve injuries. The clinical use
of Schwann cells (SCs), however, is limited because of their limited availability. An emerging …

Motor and sensory recovery following critical size peripheral nerve defects is often
incomplete. Although nerve grafting has been proposed as the gold standard, it is …

Chemical-extracted acellular nerve allografting, containing the natural nerve structure and
elementary nerve extracellular matrix (ECM), has been used for peripheral nerve-defect …

Despite the spontaneous regenerative capacity of the peripheral nervous system, large gap
peripheral nerve injuries (PNIs) require bridging strategies. The limitations and suboptimal …

Neurotrophic factors such as the glial cell line‐derived neurotrophic factor (GDNF) and brain‐
derived neurotrophic factor (BDNF) promote nerve cell survival and regeneration, but their …

Since synthetic nerve conduits do not exhibit ideal regeneration characteristics, they are
generally inadequate substitutes for autologous nerve grafts in the repair of long peripheral …

Peripheral nerve injury repair can be enhanced by Schwann cell (SC) transplantation, but
clinical applications are limited by the lack of a cell source. Thus, alternative systems for …

With the development of tissue engineering and the shortage of autologous nerve grafts in
nerve reconstruction, cell transplantation in a conduit is an alternative strategy to improve …

Cell therapy for peripheral nerve injury is a promising strategy as regenerative medicine that
restores neurological function. However, challenges remain in producing suitable and …

Peripheral nerve injuries (PNI) occur as the result of sudden trauma and can lead to life-long
disability, reduced quality of life, and heavy economic and social burdens. Although the …