Hemorrhage remains a major cause of mortality following traumatic injury in both military
and civilian settings. Lower body negative pressure (LBNP) has been used as an …

Background Balancing between opioid analgesia and respiratory depression continues to
challenge clinicians in perioperative, emergency department, and other acute care settings …

Hemorrhage is a leading cause of death in military and civilian settings, and~ 85% of
potentially survivable battlefield deaths are hemorrhage-related. Soldiers and civilians are …

Background Tactical Combat Casualty Care guidelines for hemorrhage recommend
resuscitation to systolic blood pressure (SBP) of 85±5 mm Hg during prehospital care …

Hemorrhage is a leading cause of death in both civilian and battlefield trauma. Survival rates
increase when victims requiring immediate intervention are correctly identified in a mass …

Background—Morphine and other opioids continue to be used as the major treatment for
acute pain both before and after surgery. In this regard, much research has focused on the …

BACKGROUND Peripheral vasoconstriction is the most critical compensating mechanism
following hemorrhage to maintain blood pressure. On the battlefield, ketamine rather than …

In humans, morphine induces hypotension, probably because of histamine liberation. Earlier
animal studies have, however, suggested that morphine can induce immediate …

Lower body negative pressure (LBNP) simulates hemorrhage, and tolerance to LBNP (time
to presyncope [TTP]) is indicative of tolerance to blood loss. The purpose of this study was to …

IMPLICATIONS: Presentation of essential hypertension should be considered when opioid
regimens are planned both during surgery (to minimize cardiovascular complications) and …