The lens is an avascular organ composed of an anterior epithelial cell layer and fiber cells
that form the bulk of the organ. The lens expresses connexin43 (Cx43), connexin46 (Cx46) …

Gap junctions are composed of proteins called connexins (Cx) and facilitate both ionic and
biochemical modes of intercellular communication. In the lens, Cx46 and Cx50 provide the …

Mutations in Connexin50 (Cx50) cause cataracts in both humans and mice. The mechanism
(s) behind how mutated connexins lead to a variety of cataracts have yet to be fully …

In the last decade or so, increasing evidences suggest that the mutations of two connexin
genes, GJA3 and GJA8, are directly linked to human congenital cataracts in North and …

Purpose.: Although many connexin46 (Cx46) mutants have been linked to inherited human
cataracts, there are no adequate animal models for their study. The current experiments …

The avascular lens of the eye is covered anteriorly by an epithelium containing nucleated,
metabolically active cells. This epithelium contains the first lens cells to encounter noxious …

Connexin channels play a critical role in maintaining metabolic homeostasis and
transparency of the lens. Mutations in connexin genes are linked to congenital cataracts in …

Cataract is a common disease in the aging population. Gap junction has been considered a
central component in maintaining homeostasis for preventing cataract formation. Gap …

Mutations within connexin50 (Cx50) have been linked to various cataract phenotypes. To
determine the mechanism behind cataract formation we used the paired Xenopus oocyte …

The human lens is an avascular organ, and its transparency is dependent on gap junction
(GJ)-mediated microcirculation. Lens GJs are composed of three connexins with Cx46 and …