Interferon signalling and non-canonical inflammasome activation promote host protection against multidrug-resistant Acinetobacter baumannii
Multidrug-resistant (MDR) Acinetobacter baumannii are of major concern worldwide due to
their resistance to last resort carbapenem and polymyxin antibiotics. To develop an effective …
their resistance to last resort carbapenem and polymyxin antibiotics. To develop an effective …
GBP1 promotes killing of multidrug-resistantAcinetobacter baumanniiand promotes host protection via interferon signalling and inflammasome activation
Multidrug resistant (MDR) Acinetobacter baumannii are of major concern worldwide due to
their resistance to last resort carbapenem and polymyxin antibiotics. To develop an effective …
their resistance to last resort carbapenem and polymyxin antibiotics. To develop an effective …
GBP1 promotes killing of multidrug-resistant Acinetobacter baumannii and promotes host protection via interferon signalling and inflammasome activation
Multidrug resistant (MDR) Acinetobacter baumannii are of major concern worldwide due to
their resistance to last resort carbapenem and polymyxin antibiotics. To develop an effective …
their resistance to last resort carbapenem and polymyxin antibiotics. To develop an effective …
[HTML][HTML] NLRP3 inflammasome pathway has a critical role in the host immunity against clinically relevant Acinetobacter baumannii pulmonary infection
N Dikshit, SD Kale, HJ Khameneh, V Balamuralidhar… - Mucosal …, 2018 - Elsevier
The opportunistic Gram-negative bacterium Acinetobacter baumannii (AB) is a leading
cause of life-threatening nosocomial pneumonia. Outbreaks of multidrug resistant (MDR)-AB …
cause of life-threatening nosocomial pneumonia. Outbreaks of multidrug resistant (MDR)-AB …
Differential activation of NLRP3 inflammasome by Acinetobacter baumannii strains
Acinetobacter baumannii is an emerging nosocomial, opportunistic pathogen with growing
clinical significance globally. A. baumannii has an exceptional ability to rapidly develop drug …
clinical significance globally. A. baumannii has an exceptional ability to rapidly develop drug …
Guanylate-binding protein-dependent noncanonical inflammasome activation prevents Burkholderia thailandensis-induced multinucleated giant cell formation
Inflammasomes are cytosolic multiprotein signaling complexes that are activated upon
pattern recognition receptor-mediated recognition of pathogen-derived ligands or …
pattern recognition receptor-mediated recognition of pathogen-derived ligands or …
NLRP3 inflammasome mediates interleukin‐1β production in immune cells in response to Acinetobacter baumannii and contributes to pulmonary inflammation in …
MJ Kang, SG Jo, DJ Kim, JH Park - Immunology, 2017 - Wiley Online Library
Acinetobacter baumannii is a multi‐drug resistant, Gram‐negative bacteria and infection
with this organism is one of the major causes of mortality in intensive care units …
with this organism is one of the major causes of mortality in intensive care units …
Caspase-11 plays a protective role in pulmonary Acinetobacter baumannii infection
W Wang, Y Shao, S Li, N Xin, T Ma, C Zhao… - Infection and …, 2017 - Am Soc Microbiol
Activation of caspase-11 by some Gram-negative bacteria triggers the caspase-1/interleukin
1β (IL-1β) pathway, independent of canonical inflammasomes. Acinetobacter baumannii is a …
1β (IL-1β) pathway, independent of canonical inflammasomes. Acinetobacter baumannii is a …
[PDF][PDF] Detrimental type I interferon signaling dominates protective AIM2 inflammasome responses during Francisella novicida infection
Interferons (IFNs) and inflammasomes are essential mediators of anti-microbial immunity.
Type I IFN signaling drives activation of the AIM2 inflammasome in macrophages; however …
Type I IFN signaling drives activation of the AIM2 inflammasome in macrophages; however …
Outer membrane protein A inhibits the degradation of caspase-1 to regulate NLRP3 inflammasome activation and exacerbate the Acinetobacter baumannii pulmonary …
Y Li, C Peng, D Zhao, L Liu, B Guo, M Shi, Y Xiao… - Microbial …, 2021 - Elsevier
Abstract Acinetobacter baumannii (A. baumannii), one of the major pathogens that causes
severe nosocomial infections, is characterised by a high prevalence of drug resistance. It …
severe nosocomial infections, is characterised by a high prevalence of drug resistance. It …