Nitric oxide (NO) is a gaseous signalling molecule that plays diverse physiological functions
including antimicrobial host defence. During microbial infection, NO is synthesized by …

Streptococcus pneumoniae, a leading cause of invasive pneumococcal disease, is
responsible for high mortality and morbidity worldwide. A previous study showed that the …

The NLRC4 inflammasome is responsible for IL-1β processing by macrophages in response
to Pseudomonas aeruginosa infection. We therefore hypothesized that mice that lack ASC …

Inflammasomes are intracellular signaling complexes that are assembled in response to a
variety of pathogenic or physiologic stimuli to initiate inflammatory responses. Ubiquitously …

Dysregulated activation of the inflammasome–caspase-1–IL-1β axis elicits damaging
hyperinflammation during critical illnesses, such as pneumonia and sepsis. However, in …

Hosts recognize cytosolic microbial infection via the nucleotide-binding domain-like receptor
(NLR) protein family, triggering inflammasome complex assembly to provoke pyroptosis or …

Inflammasomes are signalling platforms that are assembled in response to infection or
sterile inflammation by cytosolic pattern recognition receptors. The consequent …

Streptococcus pneumoniae is a Gram-positive, extracellular bacterium that is responsible for
significant mortality and morbidity worldwide. Pneumolysin (PLY), a cytolysin produced by …

The non-canonical inflammasome pathway functions as the primary cytosolic innate immune
detection mechanism for Gram-negative bacterial lipopolysaccharide (LPS) in human and …

The innate immune system acts as the first line of defense against infection. One key
component of the innate immune response to gram-negative bacterial infections is …