Glioblastoma multiforme (GBM) is the most common form of primary brain cancer and has
the highest morbidity rate and current treatments result in a bleak 5-year survival rate of …

Malignant gliomas (MGs) are the most common and devastating primary brain tumor. At
present, surgical interventions, radiotherapy, and chemotherapy are only marginally …

Glioblastoma (GBM) is the most aggressive malignant brain tumor and is associated with a
very poor prognosis. The standard treatment for newly diagnosed patients involves total …

Introduction: Glioblastoma multiforme (GBM) is the most prevalent primary neoplasm of the
brain. Moreover, the prognosis of patients with GBM has been poor, with almost uniform …

Publisher Summary This chapter describes the advantages of interstitial drug delivery to the
central nervous system (CNS) using controlled release polymers. It discusses the possibility …

Glioblastoma (GBM) is a highly aggressive and heterogeneous form of brain cancer.
Genotypic and phenotypic heterogeneity drives drug resistance and tumor recurrence …

The advent of interstitial chemotherapy has significantly increased therapeutic options for
patients with malignant glioma. Interstitial chemotherapy can deliver high concentrations of …

The therapy of brain tumors has been limited by a lack of effective methods of drug delivery
to the brain. Systemic administration is often associated with toxic side effects and ultimately …

We have developed a systematic approach for the discovery and evaluation of local
treatment strategies for brain tumors using polymers. We demonstrated the feasibility of …

Glioblastoma (GBM) is an aggressive malignant cancer associated with bleak prognosis and
high mortality. The current standard of care for GBM is maximum surgical resection plus …