[HTML][HTML] In-/off-label use of biologic therapy in systemic lupus erythematosus

M Gatto, E Kiss, Y Naparstek, A Doria - BMC medicine, 2014 - Springer
Current therapies for systemic lupus erythematosus (SLE) include corticosteroids as a
persistent mainstay and traditional immunosuppressants which are given according to …

Long-term open-label continuation study of the safety and efficacy of belimumab for up to 7 years in patients with systemic lupus erythematosus from Japan and South …

Y Tanaka, SC Bae, D Bass, P Curtis, M Chu… - RMD open, 2021 - rmdopen.bmj.com
Objectives To evaluate the long-term safety and efficacy of belimumab in patients with
systemic lupus erythematosus (SLE) from Japan and South Korea. Methods In this phase III …

The safety of belimumab for the treatment of systemic lupus erythematosus

LM Wise, W Stohl - Expert Opinion on Drug Safety, 2019 - Taylor & Francis
Introduction: Systemic lupus erythematosus (SLE) is a systemic autoimmune inflammatory
disease with extensive clinical variability. In 2011, the anti-BAFF monoclonal antibody …

Smoking and pre-existing organ damage reduce the efficacy of belimumab in systemic lupus erythematosus

I Parodis, C Sjöwall, A Jönsen, D Ramsköld… - Autoimmunity …, 2017 - Elsevier
Objectives Belimumab is the first biologic drug approved for Systemic Lupus Erythematosus
(SLE). Here, we aimed to investigate the effects of belimumab on clinical and serologic …

Efficacy and safety of subcutaneous belimumab in systemic lupus erythematosus: a fifty‐two–week randomized, double‐blind, placebo‐controlled study

W Stohl, A Schwarting, M Okada… - Arthritis & …, 2017 - Wiley Online Library
Objective To assess the efficacy and safety of subcutaneous (SC) belimumab in patients
with systemic lupus erythematosus (SLE). Methods Patients with moderate‐to‐severe SLE …

Disease control and safety of belimumab plus standard therapy over 7 years in patients with systemic lupus erythematosus

EM Ginzler, DJ Wallace, JT Merrill, RA Furie… - The Journal of …, 2014 - jrheum.org
Objective. To evaluate the efficacy/safety of belimumab plus standard therapy in patients (n=
449) with active systemic lupus erythematosus (SLE) treated up to 7 years (n= 177 currently …

A phase II, randomized, double‐blind, placebo‐controlled, dose‐ranging study of belimumab in patients with active systemic lupus erythematosus

DJ Wallace, W Stohl, RA Furie, JR Lisse… - Arthritis Care & …, 2009 - Wiley Online Library
Objective To assess the safety, tolerability, biologic activity, and efficacy of belimumab in
combination with standard of care therapy (SOC) in patients with active systemic lupus …

Why targeted therapies are necessary for systemic lupus erythematosus

L Durcan, M Petri - Lupus, 2016 - journals.sagepub.com
Systemic lupus erythematosus (SLE) continues to have important morbidity and accelerated
mortality despite therapeutic advances. Targeted therapies offer the possibility of improved …

Belimumab for systemic lupus erythematosus–Focus on lupus nephritis

M Plüß, S Piantoni, B Tampe, AHJ Kim… - Human Vaccines & …, 2022 - Taylor & Francis
In recent years, advances in the treatment and management of patients with systemic lupus
erythematosus (SLE) have improved their life expectancy and quality of life. However, lupus …

[PDF][PDF] Clinical outcomes in patients with systemic lupus erythematosus treated with belimumab in clinical practice settings: a retrospective analysis of results from the …

J von Kempis, S Duetsch, N Reuschling, R Villiger… - Swiss medical …, 2019 - smw.ch
AIMS OF THE STUDY To describe patterns of systemic lupus erythematosus (SLE) care and
the clinical effectiveness of belimumab plus standard of care therapy in a real-world clinical …