Stem cells have the capacity to differentiate into various lineages, and the ability to reliably
direct stem cell fate determination would have tremendous potential for basic research and …

During embryogenesis and tissue maintenance and repair in an adult organism, a myriad of
stem cells are regulated by their surrounding extracellular matrix (ECM) enriched with …

There is a rapidly growing body of literature on the effects of topography and critically,
nanotopography on cell adhesion, apoptosis and differentiation. Understanding the effects …

The interplay of biophysical and biochemical cues in the extracellular microenvironment
regulate and control the cell fate of stem cells. Understanding the interaction between stem …

Adult stem cells hold great promise as a source of diverse terminally differentiated cell types
for tissue engineering applications. However, due to the complexity of chemical and …

Current load-bearing orthopaedic implants are produced in 'bio-inert'materials such as
titanium alloys. When inserted into the reamed bone during hip or knee replacement surgery …

The interaction of mammalian cells with nanoscale topography has proven to be an
important signaling modality in controlling cell function. Naturally occurring nanotopographic …

Influencing cell behavior from proliferation to differentiation using substrate or implant
topography is an attractive strategy for regenerative medicine applications. Substrate …

Human tissues are intricate ensembles of multiple cell types embedded in complex and well-
defined structures of the extracellular matrix (ECM). The organization of ECM is frequently …

Stem cells are increasingly studied because of their potential to underpin a range of novel
therapies, including regenerative strategies, cell type-specific therapy and tissue repair …