Leptin is an adipose tissue hormone that functions as an afferent signal in a negative
feedback loop that maintains homeostatic control of adipose tissue mass. This endocrine …

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine
function, metabolism, immune function and other systems through its effects on the central …

The discovery of leptin changed the view of adipose tissue from that of a passive vessel that
stores fat to that of a dynamic endocrine organ that actively regulates behaviour and …

THE DISCOVERY of leptin in 1994 has provided a major new piece in the puzzle of obesity.
Leptin is a 167-amino acid peptide made exclusively in adipose tissue. Its absence …

Historically, adipose tissue was considered to be a passive storage vessel discharging
nutrients in times of famine and accumulating fat in times of surfeit. This view changed with …

Leptin is an adipocyte hormone that signals nutritional status to the central nervous system
(CNS) and peripheral organs. Leptin is also synthetized in the placenta and in …

The discovery of leptin has provided a robust framework upon which our current
understanding of the mechanisms involved in energy homeostasis has been built. In this …

The hyperphagia, low sympathetic nervous system tone, and decreased circulating
concentrations of bioactive thyroid hormones that are common to states of congenital leptin …

Leptin is an adipokine and its name derives from the Greek word lepto 2 (leptos), which
means thin. Since its initial discovery in 1994, important advances have been made, and …