Abstract Cyclin-dependent kinase 5 (CDK5) is the serine/threonine-directed kinase mainly
found in the brain and plays a significant role in developing the central nervous system …

Alzheimer's disease (AD) is one of the most frequently encountered diseases in adults with
progressive loss of memory and behavioral changes. Inspite of there being an intense …

Deregulation of cyclin-dependent kinases (CDKs) has been associated with many cancer
types and has evoked an interest in chemical inhibitors with possible therapeutic benefit …

Introduction Cyclin-dependent kinase 7 (CDK7) is a member of the CDK family of
serine/threonine protein kinases and participates in the regulation of the cell cycle and …

Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine (ser)/threonine (Thr) kinase
that has been demonstrated to be one of the most functionally diverse kinases within …

Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine protein kinase, which forms active
complexes with p35 or p39 expressed predominantly in neurons. Cdk5 is indispensable for …

Cyclin-dependent kinase 5 (CDK5) is a serine/threonine protein kinase and its deregulation
is implicated in a number of neurodegenerative disorders such as Alzheimer's disease …

Neurological disorders are a group of disorders with motor, sensory or cognitive damage,
caused by dysfunction of the central or peripheral nervous system. Cyclin-dependent …

Cyclin-dependent kinases 5 (Cdk5) is a special member of proline-directed serine threonine
kinase family. Unlike other Cdks, Cdk5 is not directly involved in cell cycle regulation but …

Selective abrogation of cyclin-dependent kinases (CDK) activity is a highly promising
strategy in cancer treatment. The atypical CDK, CDK5 has long been known for its role in …