Objective To investigate the role and characterize the molecular mechanisms regulating
apoptosis and autophagy in nitric oxide (NO)–induced chondrocyte cell death. Design Cell …

Osteoarthritis (OA) is the most prevalent chronic joint disease with an immense
socioeconomic burden; however, no treatment has achieved complete success in effectively …

Despite the numerous studies of protein kinase CK2, little progress has been made in
understanding its function in chondrocyte death. Our previous study first demonstrated that …

Cell death with morphological and molecular features of apoptosis has been detected in
osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the …

The present study aimed to analyze the responses to autophagy in osteoarthritis (OA) and
aging chondrocytes in order to elucidate the role of autophagy in the pathogenesis of OA …

The death of chondrocytes and the loss of extracellular matrix are the central features in
cartilage degeneration during Osteoarthritis (OA) pathogenesis. The mechanism by which …

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that eventually leads
to joint deformities and loss of joint function. Previous studies have demonstrated a close …

Osteoarthritis (OA) is a degenerative disease in which a low-grade inflammation in cartilage
and synovium occurs, causing a deterioration of cartilage and the consequent joint disability …

Objective. Autophagy is a potential protective mechanism that is involved in several
degenerative diseases. Nitric oxide (NO) is associated with programmed cellular death in …

Osteoarthritis (OA) is the main pathogenic factor in diseases that cause joint deformities. As
the main manifestation of the progress of OA, cartilage degradation has been closely …