A high‐fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the AppNL−F/NL−F knock‐in mouse model

G Mazzei, R Ikegami, N Abolhassani, N Haruyama… - Aging cell, 2021 - Wiley Online Library
Insulin resistance and diabetes mellitus are major risk factors for Alzheimer's disease (AD),
and studies with transgenic mouse models of AD have provided supportive evidence with …

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice

M Hiltunen, VKM Khandelwal, N Yaluri… - Journal of cellular …, 2012 - Wiley Online Library
According to epidemiological studies, type‐2 diabetes increases the risk of Alzheimer's
disease. Here, we induced hyperglycaemia in mice overexpressing mutant amyloid …

Progressive neuronal pathology and synaptic loss induced by prediabetes and type 2 diabetes in a mouse model of Alzheimer's disease

JJ Ramos-Rodriguez, T Spires-Jones, AM Pooler… - Molecular …, 2017 - Springer
Age remains the main risk factor for developing Alzheimer's disease (AD) although certain
metabolic alterations, including prediabetes and type 2 diabetes (T2D), may also increase …

Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's disease

L Devi, MJ Alldred, SD Ginsberg, M Ohno - PloS one, 2012 - journals.plos.org
Although evidence is accumulating that diabetes mellitus is an important risk factor for
sporadic Alzheimer's disease (AD), the mechanisms by which defects in insulin signaling …

Glucose tolerance and insulin sensitivity are impaired in APP/PS1 transgenic mice prior to amyloid plaque pathogenesis and cognitive decline

L Macklin, CM Griffith, Y Cai, GM Rose, XX Yan… - Experimental …, 2017 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by beta-
amyloid (Aβ) deposition, neurofibrillary tangles and cognitive decline. Clinical data suggests …

Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

L Ho, W Qin, PN Pompl, Z Xiang, J Wang… - The FASEB …, 2004 - Wiley Online Library
Recent epidemiological evidence indicates that insulin resistance, a proximal cause of Type
II diabetes [a non‐insulin dependent form of diabetes mellitus (NIDDM)], is associated with …

Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes

M Shinohara, Y Tashiro, M Shinohara… - The FASEB …, 2020 - Wiley Online Library
Clinical studies have indicated that obesity and diabetes are associated with Alzheimer's
disease (AD) and neurodegeneration. Although the mechanisms underlying these …

Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice

M Maesako, K Uemura, M Kubota, A Kuzuya… - Neurobiology of …, 2012 - Elsevier
The pathogenesis of Alzheimer's disease (AD) is tightly associated with metabolic
dysfunctions. In particular, a potential link between type 2 diabetes (T2DM) and AD has …

Insulin reverses the high-fat diet–induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease

M Vandal, PJ White, C Tremblay, I St-Amour… - Diabetes, 2014 - Am Diabetes Assoc
Defects in insulin production and signaling are suspected to share a key role in diabetes
and Alzheimer disease (AD), two age-related pathologies. In this study, we investigated the …

Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic …

M Maesako, K Uemura, M Kubota, A Kuzuya… - Journal of Biological …, 2012 - ASBMB
Accumulating evidence suggests that some dietary patterns, specifically high fat diet (HFD),
increase the risk of developing sporadic Alzheimer disease (AD). Thus, interventions …