Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome

FK Barreto, R Khouri, FF de Almeida Rego… - Infection, Genetics and …, 2016 - Elsevier
The region known as pX in the 3′ end of the human T-cell lymphotropic virus type 1 (HTLV-
1) genome contains four overlapping open reading frames (ORF) that encode regulatory …

[HTML][HTML] Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis

S Nozuma, E Matsuura, D Kodama, Y Tashiro… - Retrovirology, 2017 - Springer
Background Although human T-lymphotropic virus type 1 (HTLV-1) infection is a prerequisite
for the development of HTLV-1-associated myelopathy/tropical spastic paraparesis …

High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell …

OM Espíndola, LC Oliveira, P Ferreira, ACCB Leite… - Intervirology, 2015 - karger.com
Background/Aims: Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that
causes a persistent infection, and only 0.5-5% of infected individuals will develop HTLV-1 …

[HTML][HTML] An insight to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis; evidence from high-throughput data integration and meta …

SH Mozhgani, M Piran, M Zarei-Ghobadi, M Jafari… - Retrovirology, 2019 - Springer
Background Human T-lymphotropic virus 1-associated myelopathy/tropical spastic
paraparesis (HAM/TSP) is a progressive disease of the central nervous system that …

Frequency of p12K and p12R alleles of HTLV type 1 in HAM/TSP patients and in asymptomatic HTLV type 1 carriers

ML Martins, BC Soares, JG Ribas… - AIDS research and …, 2002 - liebertpub.com
HTLV-1 has a complex genome, and contains four open reading frames (ORFs) in the 3′
region encoding viral and cellular regulatory proteins. p12 is a small, ORF I-encoded …

[HTML][HTML] HTLV-1 integration into transcriptionally active genomic regions is associated with proviral expression and with HAM/TSP

KN Meekings, J Leipzig, FD Bushman, GP Taylor… - PLoS …, 2008 - journals.plos.org
Human T-lymphotropic virus type 1 (HTLV-1) causes leukaemia or chronic inflammatory
disease in∼ 5% of infected hosts. The level of proviral expression of HTLV-1 differs …

Altered Expression of Degranulation-Related Genes in CD8+ T Cells in Human T Lymphotropic Virus Type I Infection

TM Malta, IT Silva, DG Pinheiro… - AIDS research and …, 2013 - liebertpub.com
Human T lymphotropic virus type I (HTLV-1) is the etiological agent of HTLV-1-associated
myelopathy/tropical spastic paraparesis (HAM/TSP). CD8+ T cells may contribute to the …

Evaluation of host genetic and viral factors as surrogate markers for HTLV‐1‐associated myelopathy/tropical spastic paraparesis in Peruvian HTLV‐1‐infected …

M Talledo, G Lopez, JR Huyghe… - Journal of medical …, 2010 - Wiley Online Library
Human T‐lymphotropic virus 1 (HTLV‐1)‐associated myelopathy/tropical spastic
paraparesis (HAM/TSP) is a complication that affects up to 5% of HTLV‐1‐infected …

Evaluation of HTLV‐1 HBZ and proviral load, together with host IFN λ3, in pathogenesis of HAM/TSP

SH Mozhgani, N Jaberi, SA Rezaee… - Journal of Medical …, 2017 - Wiley Online Library
Human T‐cell lymphotropic virus 1 (HTLV‐1) is associated with two progressive diseases:
HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T‐cell …

Immunogenetics and the Pathological Mechanisms of Human T‐Cell Leukemia VirusType 1‐(HTLV‐1‐) AssociatedMyelopathy/Tropical Spastic Paraparesis (HAM …

M Saito - Interdisciplinary Perspectives on Infectious Diseases, 2010 - Wiley Online Library
Human T‐cell leukemia virus type 1 (HTLV‐1) is a replication‐competent human retrovirus
associated with two distinct types of disease only in a minority of infected individuals: the …