[HTML][HTML] Deleterious effect of high-fat diet on skeletal muscle performance is prevented by high-protein intake in adult rats but not in old rats

E Poggiogalle, F Rossignon, A Carayon… - Frontiers in …, 2022 - frontiersin.org
The phenotype of sarcopenic obesity is frequently associated with impaired muscle strength
and performance. Ectopic lipid deposition may interfere with muscle anabolic response …

The effects of diet composition and chronic obesity on muscle growth and function

LGO de Sousa, AG Marshall… - Journal of Applied …, 2021 - journals.physiology.org
Diet-induced obesity (DIO) is associated with glucose intolerance, insulin resistance (IR),
and an increase in intramyocellular lipids (IMCL), which may lead to disturbances in glucose …

[HTML][HTML] Altered lipid metabolism impairs skeletal muscle force in young rats submitted to a short-term high-fat diet

DE Andrich, Y Ou, L Melbouci… - Frontiers in …, 2018 - frontiersin.org
Obesity and ensuing disorders are increasingly prevalent in young populations. Prolonged
exposure to high-fat diets (HFD) and excessive lipid accumulation were recently suggested …

The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles

GAM Messa, M Piasecki, J Hurst, C Hill… - Journal of …, 2020 - journals.biologists.com
Prolonged high-fat diets (HFDs) can cause intramyocellular lipid (IMCL) accumulation that
may negatively affect muscle function. We investigated the duration of a HFD required to …

Long‐Chain Fatty Acids and Inflammatory Markers Coaccumulate in the Skeletal Muscle of Sarcopenic Old Rats

T Laurentius, R Kob, C Fellner, M Nourbakhsh… - Disease …, 2019 - Wiley Online Library
Obesity and inflammation are reportedly associated with the pathogenesis of sarcopenia,
which is characterized by age‐related loss of skeletal muscle mass. Intramuscular fat …

Chronic high fat feeding attenuates load‐induced hypertrophy in mice

M Sitnick, SC Bodine, JC Rutledge - The Journal of physiology, 2009 - Wiley Online Library
The incidence of obesity and obesity‐related conditions, such as metabolic syndrome and
insulin resistance, is on the increase. The effect of obesity on skeletal muscle function …

Long‐term, but not short‐term high‐fat diet induces fiber composition changes and impaired contractile force in mouse fast‐twitch skeletal muscle

H Eshima, Y Tamura, S Kakehi… - Physiological …, 2017 - Wiley Online Library
In this study, we investigated the effects of a short‐term and long‐term high‐fat diet (HFD) on
morphological and functional features of fast‐twitch skeletal muscle. Male C57 BL/6J mice …

Effects of chronic high-fat feeding on skeletal muscle mass and function in middle-aged mice

SR Lee, AV Khamoui, E Jo, BS Park… - Aging clinical and …, 2015 - Springer
Background and aims Increased adipose tissue may promote catabolic events in skeletal
muscle. The aim of this study was to test whether high-fat diet (HFD)-induced obesity would …

[HTML][HTML] Amyotrophy induced by a high-fat diet is closely related to inflammation and protein degradation determined by quantitative phosphoproteomic analysis in …

Y Sun, J Huang, Z Chen, M Du, F Ren, J Luo… - The Journal of …, 2020 - Elsevier
Background: Ectopic fat accumulation in skeletal muscle results in dysfunction and atrophy,
but the underlying molecular mechanisms remain unclear. Objective: The aim of this study …

Investigating a dose–response relationship between high-fat diet consumption and the contractile performance of isolated mouse soleus, EDL and diaphragm …

J Hurst, RS James, VM Cox, C Hill, J Tallis - European Journal of Applied …, 2019 - Springer
Purpose Recent evidence has demonstrated an obesity-induced, skeletal muscle-specific
reduction in contractile performance. The extent and magnitude of these changes in relation …