Quorum-sensing regulation of antimicrobial resistance in bacteria

X Zhao, Z Yu, T Ding - Microorganisms, 2020 - mdpi.com
Quorum sensing is a cell-to-cell communication system that exists widely in the microbiome
and is related to cell density. The high-density colony population can generate a sufficient …

Development of quorum-based anti-virulence therapeutics targeting Gram-negative bacterial pathogens

SB Tay, WS Yew - International journal of molecular sciences, 2013 - mdpi.com
Quorum sensing is a cell density-dependent signaling phenomenon used by bacteria for
coordination of population-wide phenotypes, such as expression of virulence genes …

Inhibitors and antagonists of bacterial quorum sensing

N Ni, M Li, J Wang, B Wang - Medicinal research reviews, 2009 - Wiley Online Library
Bacteria can regulate community‐wide behaviors including biofilm formation, virulence,
conjugation, sporulation, and swarming motility through a process called quorum sensing …

Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?

T Bjarnsholt, M Givskov - Current infectious disease reports, 2008 - Springer
Bacterial resistance poses a major challenge to the development of new antimicrobial
agents. Conventional antibiotics have an inherent obsolescence because they select for …

Quorum sensing and bacterial pathogenicity: from molecules to disease

A Deep, U Chaudhary, V Gupta - Journal of laboratory …, 2011 - thieme-connect.com
Quorum sensing in prokaryotic biology refers to the ability of a bacterium to sense
information from other cells in the population when they reach a critical concentration (ie a …

Regulatory mechanisms and promising applications of quorum sensing-inhibiting agents in control of bacterial biofilm formation

L Zhou, Y Zhang, Y Ge, X Zhu, J Pan - Frontiers in microbiology, 2020 - frontiersin.org
A biofilm is an assemblage of microbial cells attached to a surface and encapsulated in an
extracellular polymeric substance (EPS) matrix. The formation of a biofilm is one of the …

Quorum sensing: an emerging target for antibacterial chemotherapy?

P Williams - Expert Opinion on Therapeutic Targets, 2002 - Taylor & Francis
The emergence of bacterial strains exhibiting resistance to multiple antibiotic classes poses
a major threat to medicine and public health. This has been compounded over the last few …

Messing with bacterial quorum sensing

JE González, ND Keshavan - Microbiology and Molecular Biology …, 2006 - Am Soc Microbiol
Quorum sensing is widely recognized as an efficient mechanism to regulate expression of
specific genes responsible for communal behavior in bacteria. Several bacterial phenotypes …

Resistance to quorum-quenching compounds

R García-Contreras, T Maeda… - Applied and …, 2013 - Am Soc Microbiol
Bacteria have the remarkable ability to communicate as a group in what has become known
as quorum sensing (QS), and this trait has been associated with important bacterial …

Quorum sensing: bacteria talk sense

CD Sifri - Clinical infectious diseases, 2008 - academic.oup.com
Cell communication in bacteria occurs through a vernacular of small diffusible chemical
signals that impact gene regulation during times of high cell density. This form of intercellular …