Hyperglycemia, which is a chronic metabolic condition caused by either a defect in insulin
secretion or insulin resistance, is a hallmark of diabetes mellitus (DM). Sustained …

Sažetak ATP-sensitive potassium (KATP) channels are a major drug target for the treatment
of type-2 diabetes. KATP channels are ubiquitously expressed and link the metabolic state …

ATP-sensitive K+ (KATP) channels are therapeutic targets for hypertension and diabetes.
KATP channel opening elicits vasorelaxation and myocardial protection, whereas its closing …

Background and purpose: The 2‐propyl‐1, 4 benzoxazine (AM10) shows a peculiar
behaviour in skeletal muscle, inhibiting or opening the ATP‐sensitive K+ (KATP) channel in …

Diabetes is one of the prominent metabolic disorders nowadays. It is associated with many
complications, including polyuria, weight loss, polydipsia, polyphagia, blurred vision …

The 2 H-1, 4-benzoxazine derivatives are novel drugs structurally similar to nucleotides;
however, their actions on the pancreatic β cell ATP-sensitive K+ (KATP) channel and on …

The biguanides, phenformin and metformin, are used in the treatment of type II diabetes
mellitus, as well as being routinely used in studies investigating AMPK activity. We used the …

Ionic channels are present in eucaryotic plasma and intracellular membranes. They
coordinate and control several functions. Potassium channels belong to the most diverse …

Introduction: Ensete glaucum seeds have been shown to possess antidiabetic properties.
However, the specific hypoglycemic activities of the compounds they contain remain poorly …

Type-2 Diabetes (T2D) is a metabolic disease characterized by permanent hyperglycemia,
whose development can be prevented or delayed by using therapeutic agents and …