Experimental animal models of coronary microvascular dysfunction

O Sorop, J van de Wouw, S Chandler… - Cardiovascular …, 2020 - academic.oup.com
Coronary microvascular dysfunction (CMD) is commonly present in patients with metabolic
derangements and is increasingly recognized as an important contributor to myocardial …

Pathophysiology of coronary microvascular dysfunction

F Crea, RA Montone, R Rinaldi - Circulation Journal, 2022 - jstage.jst.go.jp
Ischemic heart disease (IHD) is commonly recognized as the consequence of coronary
atherosclerosis and obstructive coronary artery disease (CAD). However, a significant …

Small animal models of cardiovascular disease: tools for the study of the roles of metabolic syndrome, dyslipidemia, and atherosclerosis

JC Russell, SD Proctor - Cardiovascular pathology, 2006 - Elsevier
INTRODUCTION: Cardiovascular disease, the leading cause of death in much of the
modern world, is the common symptomatic end stage of a number of distinct diseases and …

Perturbations in myocardial perfusion and oxygen balance in swine with multiple risk factors: a novel model of ischemia and no obstructive coronary artery disease

J van de Wouw, O Sorop, RWA van Drie… - Basic Research in …, 2020 - Springer
Comorbidities of ischemic heart disease, including diabetes mellitus (DM),
hypercholesterolemia (HC) and chronic kidney disease (CKD), are associated with coronary …

Animal models of atherosclerosis–supportive notes and tricks of the trade

A Gisterå, DFJ Ketelhuth, SG Malin… - Circulation …, 2022 - Am Heart Assoc
Atherosclerotic cardiovascular disease is a major cause of death among humans. Animal
models have shown that cholesterol and inflammation are causatively involved in the …

The pathogenic role of coronary microvascular dysfunction in the setting of other cardiac or systemic conditions

RE Konst, TJ Guzik, JC Kaski… - Cardiovascular …, 2020 - academic.oup.com
Coronary microvascular dysfunction (CMD) plays a pathogenic role in cardiac and systemic
conditions other than microvascular angina. In this review, we provide an overview of the …

Coronary microvascular dysfunction: a review of recent progress and clinical implications

R Rehan, A Yong, M Ng, J Weaver… - Frontiers in …, 2023 - frontiersin.org
The coronary microcirculation plays a cardinal role in regulating coronary blood flow to meet
the changing metabolic demands of the myocardium. Coronary microvascular dysfunction …

Coronary Microvascular Dysfunction Across the Spectrum of Cardiovascular Diseases: JACC State-of-the-Art Review

MG Del Buono, RA Montone, M Camilli… - Journal of the American …, 2021 - jacc.org
Coronary microvascular dysfunction (CMD) encompasses several pathogenetic
mechanisms involving coronary microcirculation and plays a major role in determining …

Coronary microvascular dysfunction in a porcine model of early atherosclerosis and diabetes

M van den Heuvel, O Sorop… - American Journal …, 2012 - journals.physiology.org
Detailed evaluation of coronary function early in diabetes mellitus (DM)-associated coronary
artery disease (CAD) development is difficult in patients. Therefore, we investigated …

Pharmacological approaches to coronary microvascular dysfunction

G Guarini, A Huqi, D Morrone, P Capozza… - Pharmacology & …, 2014 - Elsevier
In recent decades coronary microvascular dysfunction has been increasingly identified as a
relevant contributor to several cardiovascular conditions. Indeed, coronary microvascular …