Neuroprotective and Neurorestorative Effects of Holothuria scabra Extract in the MPTP/MPP+-Induced Mouse and Cellular Models of Parkinson's Disease

K Noonong, P Sobhon, M Sroyraya… - Frontiers in …, 2020 - frontiersin.org
Extracts from Holothuria scabra (HS) have been shown to possess anti-inflammation, anti-
oxidant and anti-cancer activities. More recently, it was shown to have neuroprotective …

Neuroprotective Effects of Gagam‐Sipjeondaebo‐Tang, a Novel Herbal Formula, against MPTP‐Induced Parkinsonian Mice and MPP+‐Induced Cell Death in SH …

JH Ko, JH Lee, B Choi, JY Park… - Evidence‐Based …, 2018 - Wiley Online Library
Parkinson's disease is a neurodegenerative disease characterized by progressive cell death
of dopaminergic neuron and following neurological disorders. Gagam‐Sipjeondaebo‐Tang …

Chinese Herbal Complex 'Bu Shen Jie Du Fang' (BSJDF) Modulated Autophagy in an MPP+‐Induced Cell Model of Parkinson's Disease

C Liu, X Huang, S Qiu, W Chen, W Li… - Evidence‐Based …, 2019 - Wiley Online Library
Autophagy plays an important role in the development of Parkinson disease (PD). Previous
studies showed that autophagy could protect cells from α‐synuclein toxicity and promote …

Glabridin attenuates MPTP-induced parkinson disease by inhibiting extracellular regulated protein kinases signaling pathway

Y Zhao, ZN Lu - Zhonghua yi xue za zhi, 2017 - europepmc.org
Objective: To investigate whether Glabridin had a beneficial effect on 1-methyl-4-phenyl-1,
2, 3, 6-tetrahydropyridine (MPTP) induced parkinson disease (PD) in mice, and explore the …

Down-regulation of oxidative stress is the possible mechanism of ginsenoside Rg1 protecting the substantia nigra neurons in PD mice1

YC ZHOU, XC CHEN, YG ZHU… - Chinese Journal of …, 2003 - manu41.magtech.com.cn
AIM: To explore the role of ginsenoside Rg1 as an antioxidant in preventing against 1-
methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced apoptosis of substantia nigra …

Protection by tetrahydroxystilbene glucoside against neurotoxicity induced by MPP+: the involvement of PI3K/Akt pathway activation

R Qin, X Li, G Li, L Tao, Y Li, J Sun, X Kang, J Chen - Toxicology Letters, 2011 - Elsevier
Oxidative stress plays an important role in the pathogenesis of Parkinson's disease (PD). 2,
3, 5, 4′-tetrahydroxystilbene-2-O-β-d-glucoside (TSG), which is an active component of the …

Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation

X Li, Y Li, J Chen, J Sun, X Li, X Sun, X Kang - Neuroscience Letters, 2010 - Elsevier
It is known that oxidative stress plays a major role in the progression of Parkinson's disease
(PD). Previous studies have suggested that 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-d …

银杏叶提取物对MPTP 诱导帕金森小鼠保护作用的研究

李金凤, 徐桂梅, 张辰子, 费帆, 杨林, 代路路, 孙侠… - 2016 - zgbjyx.cnjournals.com
Objective To investigate the therapeutical effect of Ginkgo Biloba extract (GBE) on different
ages of parkinsono Biloba e (PD) mice that induced by MPTP. Methods Sixty adult mice (8 …

Neuroprotective effects of madecassoside in early stage of Parkinson's disease induced by MPTP in rats

CL Xu, R Qu, J Zhang, LF Li, SP Ma - Fitoterapia, 2013 - Elsevier
In this study, we investigated the neuroprotective effects of madecassoside, isolated from the
Chinese medicinal herb Centella asiatica, in the rat model of early phase of parkinsonism …

Congrong Shujing Granule‐Induced GRP78 Expression Reduced Endoplasmic Reticulum Stress and Neuronal Apoptosis in the Midbrain in a Parkinson's Disease …

Q Xu, S Yang, F Wu, Y Lin, J Zhong… - Evidence‐Based …, 2020 - Wiley Online Library
The main pathological changes inherent in Parkinson's disease (PD) are degeneration and
loss of dopamine neurons in the midbrain and formation of Lewy bodies. Many studies have …