Pancreatic cancer is one of the most lethal malignancies worldwide. Although the standard
of care in pancreatic cancer has improved, prognoses for patients remain poor with a 5-year …

Angiogenesis is a crucial event in tumor development and progression, occurring by
different mechanisms and it is driven by pro-and anti-angiogenic molecules. Pancreatic …

Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, and there is a close
parallel between disease mortality and incidence. Malignancy is often diagnosed at an …

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. Althoughthe specific
mechanisms that dictate its biological aggressiveness are notclearly established, it is …

A primary inoculum of human pancreatic cancer cells (BxPC-3) has the ability to inhibit the
growth of a secondary tumor in an in vivo animal model. Such ability suggests that the …

Pancreatic ductal adenocarcinoma (PDAC) occurs in the majority of cases with early loco-
regional spread and distant metastases at diagnosis, leading to dismal prognosis with a 5 …

Deregulated angiogenesis has been identified as a key contributor in a number of
pathological conditions including cancer. It is a complex process, which involves highly …

Angiogenesis plays an important role in the development of cancer since it allows for the
delivery of oxygen, nutrients, and growth factors as well as tumor dissemination to distant …

Pancreatic cancer angiogenesis has been attributed to genetic and epigenetic alterations
(eg, oncogene activation and suppressor inactivation) and a chaotic tumor …

Tumor angiogenesis is the proliferation of a network of blood vessels that penetrates into
cancerous growths, supplying nutrients and oxygen and removing waste products. The …