The adult mammalian heart is incapable of regeneration following cardiomyocyte loss,
which underpins the lasting and severe effects of cardiomyopathy. Recently, it has become …

Although the adult mammalian heart is incapable of meaningful functional recovery
following substantial cardiomyocyte loss, it is now clear that modest cardiomyocyte turnover …

Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from
glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle …

After cessation of blood flow or similar ischaemic exposures, deleterious molecular
cascades commence in mammalian cells, eventually leading to their death,. Yet with …

Although recent studies have revealed that heart cells are generated in adult mammals, the
frequency of generation and the source of new heart cells are not yet known. Some studies …

Toxic oxygen: The radical life-giver | Nature Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Background—Hypoxia plays an important role in many biological/pathological processes. In
particular, hypoxia is associated with cardiac ischemia. which, although initially inducing a …

Cardiomyocyte (CM) replacement is very slow in adult mammalian hearts, preventing
regeneration of damaged myocardium. By contrast, fetal hearts display considerable …

Despite current treatment regimens, heart failure remains the leading cause of morbidity and
mortality in the developed world due to the limited capacity of adult mammalian ventricular …

An emerging concept is that the mammalian myocardium has the potential to regenerate, but
that regeneration might be too inefficient to repair the extensive myocardial injury that is …